Pediatric Endocrinology Diabetes and Metabolism
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ISSN: 2081-237X
Pediatric Endocrinology Diabetes and Metabolism
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Case report

Clinical puzzle of endocrine disorders in Van Wyk-Grumbach syndrome: A case report

Aleksandra Pach
1
,
Kamil Dyrka
1, 2
,
Hanna Nowak
3
,
Katarzyna Janeczek
3
,
Karina Kapczuk
4
,
Marek Niedziela
1
,
Monika Obara-Moszynska
1

  1. Department of Pediatric Endocrinology and Rheumatology, Institute of Pediatrics, Poznan University of Medical Sciences, Poland
  2. Doctoral School, Poznan University of Medical Sciences, Poland
  3. Student Scientific Society of Poznan University of Medical Sciences, Poland
  4. Division of Gynecology, Poznan University of Medical Sciences, Poland
Pediatr Endocrinol Diabetes Metab 2026; 32
DOI: https://doi.org/10.5114/pedm.2025.155103
Online publish date: 2026/02/02
Article file
- 0395_Clinical puzzle (4).pdf  [2.77 MB]
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4. Baranowski E, Hogler W. An unusual presentation of acquired hypothyroidism: the Van Wyk-Grumbach syndrome. European J Endocrinol 2011; 166: 537–542. doi:10.1530/eje-11-0494.
5. Leonardi A, Penta L, Cofini M, et al. Rhabdomyolysis in a Young Girl with Van Wyk-Grumbach Syndrome due to Severe Hashimoto Thyroiditis. Int J Environ Res Public Health 2018; 15: 704. doi: 10.3390/ijerph15040704.
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8. Zhang H, Geng N, Wang Y, et al. Van Wyk and Grumbach syndrome: two case reports and review of the published work. J Obstet Gynaecol Res 2014; 40: 607–610. doi: 10.1111/jog.12181.
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14. Moszczynska E, Kunecka K, Szalecki M. Przedwczesne dojrzewanie. In: Pediatria w praktyce lekarza POZ. Dobrzańska A, Obrycki Ł, Socha P (eds.). Media-Press, Warszawa 2023; 411–419.
15. Corica D, Aversa T, Pepe G, et al. Peculiarities of Precocious Puberty in Boys and Girls With McCune-Albright Syndrome. Front Endocrinol (Lausanne) 2018; 9: 337. doi: 10.3389/fendo.2018.00337.
16. Singhania P, Bhattarcharjee R, Chowdhury S. Van Wyk-Grumbach syndrome: a rare presentation of a common endocrine disorder. Endokrynol Pol 2022; 73: 784–785. doi: 10.5603/EP.a2022.0044.
17. Pienkowski C, Cartault A, Carfagna L, et al. Ovarian cysts in prepubertal girls. Endocr Dev 2012; 22: 101–111. doi: 10.1159/000326627.

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