eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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SCImago Journal & Country Rank
4/2012
vol. 8
 
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abstract:

Clinical research
ERCC1 intron 1 was associated with breast cancer risk

Hosseini Mojgan
,
Houshmand Massoud
,
Ebrahimi Ahmad

Arch Med Sci 2012; 8, 4: 655-658
Online publish date: 2012/09/08
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Introduction: There are numerous studies addressing associations of polymorphisms in DNA repair genes and cancer risks because accurate and efficient DNA repair is crucial to genomic integrity and fidelity. ERCC1 is important in DNA nucleotide excision repair.

Material and methods: We genotyped constitutive variants of ERCC1 in approximately 300 adults with breast adenocarcinoma and 126 controls of Iranian women. In total, 426 Iranian sporadic breast cancer affected women compared to the control group were studied by PCR-RFLP for ERCC1 variant.

Results: The genotype ERCC1 TT has the highest frequency in both groups (36.6 in patients and 8.5 in controls). The genotype ERCC1 was the most important risk factor in our population [GG/AA odds ratio: 0.692, 95% confidence interval (CI): 0.4-1.199, p = 0.188; GG/AG odds ratio: 3.333, 95% CI: 1.917-5.795, p = 0.001; AA/AG odds ratio: 0.208, 95% CI: 0.124-0.348, p = 0.342].

Conclusions: Our patients was associated with breast cancer risk.
keywords:

ERCC1 gene, polymorphism, breast cancer, MboII, polymerase chain reaction-restriction fragment length polymorphism, susceptibility factor

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