Clinical research
GABA-A receptor genes do not play a role in genetics of Lesch’s typology in Caucasian subjects
 
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Submission date: 2011-02-04
 
 
Final revision date: 2011-07-15
 
 
Acceptance date: 2011-07-24
 
 
Online publication date: 2012-05-09
 
 
Publication date: 2012-04-30
 
 
Arch Med Sci 2012;8(2):357-361
 
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ABSTRACT
Introduction: Lesch's typology differentiates alcoholics into different treatment response subgroups. The effects of ethanol are mediated, to an important extent, via the GABA-ergic system.
Material and methods: We have evaluated the linkage disequilibrium patterns and haplotype frequencies of GABRG1 and GABRA2 genes in 133 alcoholics divided according to Lesch’s typology and in 145 matched controls.
Results: Besides several relationships at a threshold of statistical significance, we found no significant differences in the haplotype distribution of these genes between alcoholics and controls.
Conclusions: Lesch’s typology may not be related with the genotype of alcoholics – at least in terms of genes with an established role in the development of dependency.
eISSN:1896-9151
ISSN:1734-1922
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