eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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2/2012
vol. 8
 
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abstract:

Clinical research
GABA-A receptor genes do not play a role in genetics of Lesch’s typology in Caucasian subjects

Anna Grzywacz
,
Iwona Małecka
,
Michał Korostyński
,
Ryszard Przewłocki
,
Przemysław Bieńkowski
,
Jerzy Samochowiec

Arch Med Sci 2012; 8, 2: 357-361
Online publish date: 2012/05/09
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Introduction: Lesch's typology differentiates alcoholics into different treatment response subgroups. The effects of ethanol are mediated, to an important extent, via the GABA-ergic system.

Material and methods: We have evaluated the linkage disequilibrium patterns and haplotype frequencies of GABRG1 and GABRA2 genes in 133 alcoholics divided according to Lesch’s typology and in 145 matched controls.

Results: Besides several relationships at a threshold of statistical significance, we found no significant differences in the haplotype distribution of these genes between alcoholics and controls.

Conclusions: Lesch’s typology may not be related with the genotype of alcoholics – at least in terms of genes with an established role in the development of dependency.
keywords:

alcohol dependence, GABA, genetics, Lesch’s typology

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