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ISSN: 1734-1922
Archives of Medical Science
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vol. 7

Clinical research
Relevance of 123I-BMIPP delayed scintigraphic imaging for patients with angina pectoris – a pilot study

Kohei Koyama
Yoshihiro J. Akashi
Keisuke Kida
Kengo Suzuki
Yuki Ishibashi
Haruki Musha
Maciej Banach

Arch Med Sci 2011; 7, 3: 428-432
Online publish date: 2011/07/11
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Introduction : The study was designed to clarify the role of 123I-β-methyl-iodophenylpentadecanoic acid (123I-BMIPP) in the evaluation of myocardial fatty acid metabolism in patients with stable angina pectoris (AP) before and after percutaneous coronary intervention (PCI).

Material and methods : Ten controls (mean age: 70.4 ±10.5 years) and 12 patients with AP (mean age: 67.4 ±11.6 years) and single vessel coronary artery disease participated in the radionuclide cardiac study. Scintigraphic images were acquired at 30 min and at 4 h after 123I-BMIPP injection to determine early and delayed BMIPP uptake, respectively. The heart-to-mediastinum (H/M) ratio and the washout rate (WR) were calculated from the planar images. All patients underwent scintigraphy one day before PCI and again 1 month after successful PCI.

Results : No significant differences in the early or delayed H/M ratios were observed between the patients and the controls before PCI (early: 2.70 ±0.36 vs. 2.73 ±0.57; delayed: 2.26 ±0.33 vs. 2.40 ±0.43; p > 0.2 for both). The early and delayed H/M ratios remained unchanged with the comparison with before PCI (early: 2.72 ±0.27, delayed: 2.23 ±0.22; p > 0.2 for both). The global WR before PCI was significantly higher in the patients than in the control group (36.7 ±9.3%, vs. 28.1 ±8.2%, p = 0.02). However, the WR after PCI did not significantly differ between the patients and the controls (34.3 ±7.8% vs. 28.1 ±8.2%, p = 0.1).

Conclusions : These data may suggest that the WR of 123I-BMIPP determined from the planar images enhances the presence of myocardial ischaemia.

angina pectoris, β-methyl-iodophenylpentadecanoic acid, delayed image, emission computed tomography

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