eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
Current issue Archive Manuscripts accepted About the journal Special issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
5/2010
vol. 6
 
Share:
Share:
more
 
 
abstract:

Clinical research
Serum neutrophil gelatinase-associated lipocalin as a marker of kidney function in pregnancy – useful or doubtful?

Jacek S. Małyszko
,
Leszek Rams
,
Lena Drozdowska-Rams
,
Jolanta Małyszko

Arch Med Sci 2010; 6, 5: 744-747
Online publish date: 2010/10/27
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction : The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C could reflect kidney function in pregnant healthy women.
Material and methods : The studies were performed on 130 healthy pregnant women (n = 63, 3rd trimester; n = 21, 2nd trimester; n = 46, 1st trimester) and 30 healthy female volunteers. Serum NGAL, cystatin C, IL-6, and hs-CRP were assayed using commercially available kits.
Results : Serum cystatin C rose steadily during the pregnancy, whereas NGAL rose in the 2nd trimester, then decreased in the 3rd trimester. In univariate analysis, NGAL correlated with serum cystatin C, number of pregnancies, white blood cell count, total iron-binding capacity (TIBC), ferritin, and IL-6, and tended to correlate with eGFR. In multiple regression analysis the only predictor of serum NGAL was cystatin C.
Conclusions : Serum NGAL in pregnancy might reflect subclinical inflammation rather than kidney function. It seems that NGAL, similarly to cystatin C, is not useful to monitor renal function in pregnancy.
keywords:

NGAL, cystatin C, pregnancy, cytokines, IL-6, eGFR, kidney function, creatinine

Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe