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eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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5/2012
vol. 50
 
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abstract:
Original paper

Collagen type I in the treatment of painful osteoarthritis of the knee

Roman Stančík
,
Jozef Zvarka
,
Marián Hlaváč
,
Vladimír Kubinec
,
Jozef Rovenský

Reumatologia 2012; 50, 5: 390–396
Online publish date: 2012/11/06
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Background: Previous studies have shown that undenatured collagen type II is effective in the treatment of both rheumatoid arthritis and osteoarthritis (OA) of the knee. The present randomized double-blind, placebo-controlled clinical trial evaluated the safety and efficacy of collagen type I (COL-I) in the treatment of OA of the knee.

Material and methods: The study group consisted of 58 patients diagnosed with knee OA (Table I). The results indicate that COL-I treatment is effective in knee OA, resulting in significant reduction in the WOMAC score and pain VAS score from the baseline after 3 months treatment and after 1 month follow-up. Treatment with COL-I reduced the total WOMAC score by 38% as compared to 10% in the placebo treated group and 37% vs. 8% after 1 month follow-up. COL-I treatment decreased the pain VAS score by 41% after 3 months treatment vs 13% in the placebo treated group and after 1 month follow-up 37% vs. 11%. Efficacy of the treatment evaluated by patients showed significantly better efficacy in the COL-I treated group compared to the placebo group (Fig. 1–3).

Results: The results of this study indicate that collagen type I is an effective treatment for symptomatic knee OA, even with a carry-over effect for at least 1 month. In addition, it also has a very good safety profile.
keywords:

collagen type I, osteoarthritis, WOMAC, visual analog scale







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