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vol. 26
 
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Original paper

Comparative effect of aerobic training vs resistance exercise on homocysteine levels and cardiovascular risk factors in type 2 diabetic individuals: a randomized clinical trial

Hanan Abdallah Elsayed
1
,
Mona Ahmed Mohamed
1
,
Akram Abdelaziz Sayed
1
,
Hanan Mohamed Farouk
2
,
Mona Abdelraouf Ghallab
1

  1. Department of Physical Therapy for Cardiopulmonary/Geriatric Disorders, Faculty of Physical Therapy, Egyptian Chinese University, Cairo, Egypt
  2. Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Family Medicine & Primary Care Review 2024; 26(2): 177–183
Online publish date: 2024/06/17
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1. Ginszt A, Ginszt M, Majcher P, et al. Effects of exercise on blood glucose levels in type 2 diabetic patients – Literature review. Pol Ann Med 2018; 25(2): 272–276.
2. Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world – a growing challenge. N Engl J Med 2007; 356(3): 213–215.
3. Krauss RM. Lipids and lipoproteins in patients with type 2 diabetes. Diabetes Care 2004; 27(6): 1496–1504.
4. Schofield JD, Liu Y, Rao-Balakrishna P, et al. Diabetes Dyslipidemia. Diabetes Ther 2016; 7(2): 203–219.
5. Platt DE, Hariri E, Salameh P, et al. Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction. Diabetol Metab Syndr 2017; 9: 19, doi: 10.1186/s13098-017-0218-0.
6. Colberg SR, Sigal RJ, Fernhall B, et al. American College of Sports Medicine, American Diabetes Association. Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care 2010; 33(12): 147–167.
7. Lee DC, Pate RR, Lavie CJ, et al. Leisure-time running reduces all-cause and cardiovascular mortality risk. J Am Coll Cardiol 2014; 64(5): 472–481.
8. Deminice R, Ribeiro DF, Frajacomo FT. The Effects of Acute Exercise and Exercise Training on Plasma Homocysteine: A Meta-Analysis. PLoS ONE 2016; 11(3): e0151653.
9. Drzewoski J, Czupryniak L, Chwatko G, et al. Hyperhomocysteinemia in poorly controlled type 2 diabetes patients. Diabetes Nutr Metab 2000; 13(6): 319–324.
10. Choudhary J, Fiza B, Sinha M, et al. Serum Homocysteine and Its Association with Lipid Profile in Type II Diabetes Mellitus. Indian J Med Biochem 2018; 22(1): 26–31.
11. Colberg SR, Sigal RJ, Yardley JE, et al. Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association. Diabetes Care 2016; 39(11): 2065–2079.
12. Diabetes Canada Clinical Practice Guidelines Expert Committee, Punthakee Z, Goldenberg R, Katz P. Definition, Classification and Diagnosis of Diabetes, Prediabetes and Metabolic Syndrome. Can J Diabetes 2018; 42(Suppl. 1): S10–S15.
13. Ferin R, Pavão ML, Baptista J. Methodology for a rapid and simultaneous determination of total cysteine, homocysteine, cysteinylglycine and glutathione in plasma by isocratic RP-HPLC. J Chromatogr B Analyt Technol Biomed Life Sci 2012; 911: 15–20.
14. Ukpanukpong RU, Uyabeme RN, Adekunle IA, et al. Biochemical Assessment of Parkia biglobosa Ethanolic Root Extract in Streptozotocin Induced Diabetic Rats. J Adv Med Pharm Sci 2017; 13(1): 1–9.
15. Herkner H, Klein N, Joukhadar C, et al. Transcapillary insulin transfer in human skeletal muscle. Eur J Clin Invest 2003; 33: 141–146.
16. But-Hadzic J, Dervisevic M, Karpljuk D, et al. Six-Minute Walk Distance in Breast Cancer Survivors – A Systematic Review with Meta-Analysis. Int J Environ Res Public Health 2021; 18(5): 2591.
17. Jach E, Świerkowski I, Kęsicki P, et al. Assessment of training heart rate in patients with chronic obstructive pulmonary disease (COPD). Fizjoter Pol 2022; 5(21): 6–12.
18. Marchese R, Hill A. The essential guide to fitness instructor. Frenchs Forest (N.S.W): Pearson Education; 2005.
19. Fox CS, Coady S, Sorlie PD, et al. Increasing cardiovascular disease burden due diabetes mellitus: the Framingham Heart Study. Circulation 2007; 115(12): 1544–1550.
20. Muniyappa R, Iantorno M, Quon MJ. An integrated view of insulin resistance and endothelial dysfunction. Endocrinol Metab Clin North Am 2008; 37(3): 685–711.
21. Thijssen DH, Black MA, Pyke KE, et al. Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol 2011; 300(1): H2–H12.
22. Huang T, Ren J, Huang J, et al. Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach. BMC Genomics 2013; 14: 867.
23. Choi JK, Moon KM, Jung SY, et al. Regular exercise training increases the number of endothelial progenitor cells and decreases homocysteine levels in healthy peripheral blood. Korean J Physiol Pharmacol 2014; 18(2): 163–168.
24. Bedada F, Ntekim O, Johnson S, et al. Exercise intervention differentially induces the expression of cystathionine beta synthase (CBS) in African American with MCI: Implication for endogenous H2S generation and component of aging pathway: Human neuropathology/amyloid. Alzheimer’s & Dementia 2020; 16, doi: 10.1002/alz.043667.
25. Wang L, Jhee KH, Hua X, et al. Modulation of cystathionine β-synthase level regulates total serum homocysteine in mice. Circ Res 2004; 94(10): 1318–1324.
26. Souza J, da Silva RA, da Luz Scheffer D, et al. Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle. Antioxidants (Basel) 2022; 11(5): 826, doi: 10.3390/antiox11050826.
27. Kaplan P, Tatarkova Z, Sivonova MK, et al. Homocysteine and mitochondria in cardiovascular and cerebrovascular systems. Int J Mol Sci 2020; 21(20): 7698, doi: 10.3390/ijms21207698.
28. Sánchez-Moreno C, Jiménez-Escrig A, Martín A. Stroke: roles of B vitamins, homocysteine and antioxidants. Nutr Res Rev 2009; 22(1): 49–67.
29. Jafari M, Bizheh N, Atri AE, et al. Acute and Chronic Effects of Physical Activity on Emerging Risk Factors of Heart Attack in Overweight Men. Int J Sport Stud Health 2019; 2(2): e94437, doi: 10.5812/intjssh.94437.
30. Herrmann M, Schorr H, Obeid R, et al. Homocysteine increases during endurance exercise. Clin Chem Lab Med 2003; 41(11): 1518–1524.
31. Ibañez J, Izquierdo M, Argüelles I, et al. Twice-weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes. Diabetes Care 2005; 28(3): 662–667.
32. E Silva ADS, Lacerda FV, da Mota MPG. The effect of aerobic vs resistance training on plasma homocysteine in individuals with type 2 diabetes. J Diabetes Metab Disord 2020; 19(2): 1003–1009.
33. Chaudhary S, Kang MK, Sandhu JS. The effects of aerobic versus resistance training on cardiovascular fitness in obese sedentary females. Asian J Sports Med 2010; 1(4): 177–184.
34. Soori R, Rezaeian N, Khosravi N, et al. Effects of water-based endurance training, resistance training, and combined water and resistance training programs on visfatin and ICAM-1 levels in sedentary obese women. Sci Sports 2017; 32(3): 144–151.
35. Harrison M, Moyna NM, Zderic TW, et al. Lipoprotein particle distribution and skeletal muscle lipoprotein lipase activity after acute exercise. Lipids Health Dis 2012; 11: 64, doi: 10.1186/1476-511X-11-64.
36. Tseng ML, Ho CC, Chen SC, et al. A simple method for increasing levels of high-density lipoprotein cholesterol: a pilot study of combination aerobic-and resistance-exercise training. Int J Sport Nutr Exerc Metab 2013; 23(3): 271–281.
37. Hsu CS, Chang ST, Nfor ON, et al. Effects of regular aerobic exercise and resistance training on high-density lipoprotein cholesterol levels in Taiwanese adults. Int J Environ Res Public Health 2019; 16(11): 2003, doi: 10.3390/ijerph16112003.
38. Gavin C, Sigal RJ, Cousins M, et al. Resistance exercise but not aerobic exercise lowers remnant-like lipoprotein particle cholesterol in type 2 diabetes: a randomized controlled trial. Atherosclerosis 2010; 213(2): 552–557.
39. Stanford KI, Goodyear LJ. Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle. Adv Physiol Educ 2014; 38(4): 308–314.
40. Abd El-Kader SM. Aerobic versus resistance exercise training in modulation of insulin resistance, adipocytokines and inflammatory cytokine levels in obese type 2 diabetic patients. J Adv Res 2011; 2(2): 179–183.
41. Lee S, Bacha F, Hannon T, et al. Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial. Diabetes 2012; 61(11): 2787–2795.
42. Suh S, Jeong IK, Kim MY, et al. Effects of resistance training and aerobic exercise on insulin sensitivity in overweight Korean adolescents: a controlled randomized trial. Diabetes Metab J 2011; 35(4): 418–426.
43. Fajriyah N, Arifin H, Rohmah UN. Effectiveness of land-based and aquatic physical exercise on physical fitness, depression status and quality of life in diabetes mellitus type 2: a systematic review. Synthesis Glob Health J 2023; 1(1): 36–51.
44. Mei N, Chang Y. Effect of aerobic exercise on physical function indices in the elderly. Rev Bras Med Esporte 2023, doi: 10.1590/1517-8692202329012022_0236.
45. Diaz-Canestro C, Montero D. The impact of sex on left ventricular cardiac adaptations to endurance training: a systematic review and meta-analysis. Sports Med 2020; 50(8): 1501–1513.
46. Zhou Y. Impacts of resistance exercise on performance in swimmers. Rev Bras Med Esporte 2023; 29: e2023_0083, doi: 10.1590/1517-8692202329012023_0083.
47. Abrahão MI, Gomiero AB, Peccin MS, et al. Cardiovascular training vs resistance training for improving quality of life and physical function in patients with systemic lupus erythematosus: a randomized controlled trial. Scand J Rheumatol 2016; 45(3): 197–201.
48. Winters-Stone KM, Torgrimson-Ojerio B, Dieckmann NF, et al. A randomized-controlled trial comparing supervised aerobic training to resistance training followed by unsupervised exercise on physical functioning in older breast cancer survivors. J Geriatr Oncol 2022; 13(2): 152–160.
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