eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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3/2019
vol. 15
 
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Obstetrics and gynecology
abstract:
Clinical research

Comparison between cycles of the same patients when using recombinant luteinizing hormone + recombinant follicle stimulating hormone (rFSH), human menopausal gonadotropin + rFSH and rFSH only

Ahter Tanay Tayyar, Semra Kahraman

Arch Med Sci 2019; 15 (3): 673–679
Online publish date: 2018/01/08
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Introduction
Recombinant follicle stimulating hormone (rFSH), recombinant luteinizing hormone (rLH), and urinary human menopausal gonadotropin (uHMG) are widely used for controlled ovarian stimulation (COS). This study compares the effects of rFSH only, rLH + rFSH, and HMG + rFSH administration on in vitro fertilization (IVF) outcomes for patients in three different yearly follow-up cycles.

Material and methods
This retrospective, single-center cohort study was conducted from January 2001 to June 2016 at Istanbul Memorial Hospital, Artificial Reproductive Technology Center. From a total of 27,024 IVF cycles in women aged 18 to 45 years (17,536 rFSH only; 2147 rLH + rFSH; 7341 HMG + rFSH), the results of 2,147 cycles receiving a treatment of rLH + rFSH over the 3-year evaluation and 2,081 total cycles in which rLH + rFSH was used at least once were evaluated, and different gonadotropin combinations were compared.

Results
The age and body mass index of the patients in the uHMG + rFSH group were found to be significantly higher than those of the patients in the rLH + rFSH and rFSH only groups (p < 0.001). The total gonadotropin (GND) dosage of the patients in the rLH + rFSH group was found to be significantly lower than that of the HMG + rFSH group (p = 0.001). No statistically significant differences were found between the clinical and ongoing pregnancy rates, while the highest clinical and ongoing pregnancy rate was observed in the rLH + rFSH group at age 35–39 years.

Conclusions
Recombinant luteinizing hormone administration may increase the number of clinical pregnancies for patients aged 35–39 years.

keywords:

infertility, luteinizing hormone, recombinant follicle stimulating hormone, recombinant luteinizing hormone, human menopausal gonadotropin, in vitro fertilization

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