eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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2/2023
vol. 40
 
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abstract:
Original paper

Comparison of olopatadine with ketotifen for allergic conjunctivitis: a meta-analysis study

Shiyu Li
1
,
Shenquan Zhong
1

  1. Department of Ophthalmology, The First People’s Hospital of Chongqing Liangjiang New Area, Chongqing, China
Adv Dermatol Allergol 2023; XL (2): 326-330
Online publish date: 2023/05/31
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Introduction:
Allergic conjunctivitis is one of the most common non-traumatic extraocular inflammatory diseases.

Aim:
Allergic conjunctivitis is one of the most common non-traumatic extraocular inflammatory diseases.

Material and methods:
PubMed, Embase, Web of Science, EBSCO, and Cochrane library databases were systematically searched, and we included randomized controlled trials (RCTs) assessing the effect of olopatadine versus ketotifen on efficacy in patients with allergic conjunctivitis. Seven RCTs were included in the meta-analysis.

Results:
Overall, compared with ketotifen intervention for allergic conjunctivitis, olopatadine intervention was associated with substantially lower hyperaemia (mean difference (MD) = –0.77; 95% confidence interval (CI) = –1.24 to –0.30; p = 0.001), but demonstrated no significant impact on itching, tearing or papillae.

Conclusions:
These suggested that olopatadine may be more effective to relieve the symptoms of allergic conjunctivitis than ketotifen.

keywords:

allergic conjunctivitis, olopatadine, ketotifen, meta-analysis

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