eISSN: 2083-8441
ISSN: 2081-237X
Pediatric Endocrinology Diabetes and Metabolism
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1/2020
vol. 26
 
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abstract:
Original paper

Comparison of sirtuin 1 level and related blood factors in diabetic and healthy subjects

Mehrali Rahimi
1
,
Somayeh Ghanbari
2
,
Mozafar Khazaei
3
,
Elham Niroman
2

1.
Department of Internal Medicine, Associate Professor of Endocrinology and Metabolism, Kermans-hah University of Medical Sciences, Kermanshah, Iran
2.
Department of Internal Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
3.
Fertility and Infertility Research Center, Health Technology Institute, Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Pediatr Endocrinol Diabetes Metab 2020; 26 (1): 17–21
Online publish date: 2020/04/25
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Introduction
Diabetes (II) is a chronic metabolic disease with many side effects. Sirtuin 1 (SIRT1) regulates prominent cellular processes such as apoptosis, aging, and metabolism of the cell, and it seems to play an important role in type 2 diabetes.

The aim of the study
was to compare the serum level of SIRT1 and related biochemical factors in patients with controlled and uncontrolled diabetes with healthy subjects.

Methods
Type 2 diabetic patients were randomly divided into controlled and uncontrolled fasting blood glucose (FBG) and healthy individuals as the control group (n = 50/group). Serum levels of SIRT1, haemoglobin A1C (HbA1c), low-density lipoprotein (LDL), high-density lipo-protein (HDL), triglyceride (TG), FBG, and body mass index (BMI) were evaluated.

Results
The mean ±SD level of SIRT1 in the uncontrolled diabetic group (3.96 ±2.52) was significantly (p < 0.001) lower than that of the con-trolled diabetic (9.22 ±4.11) and healthy subjects (10.65 ±2.2). The levels of HbA1c, FBG, LDL, HDL, and TG indicated significant differences between the groups (p < 0.05). There was a significant reverse correlation between SIRT1 with HbA1c, FBG, age, and BMI (p < 0.05) and a positive significant correlation between BMI and HbA1c (p = 0.007).

Conclusions
Sirtuin 1 is associated with improving glucose homeostasis. Therefore, it can be considered as a new therapeutic target for prevention and treatment of type 2 diabetes.

keywords:

diabetes mellitus, sirtuin 1, haemoglobin A1c, FBG

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