eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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5/2013
vol. 51
 
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abstract:
Review paper

Concentration of methotrexate in red blood cells and its relevance for disease activity in patients with rheumatoid arthritis

Sylwia Elert-Kopeć
,
Małgorzata Tłustochowicz
,
Laura Załucka
,
Grzegorz Kopeć
,
Witold Tłustochowicz

Reumatologia 2013; 51, 5: 370-374
Online publish date: 2013/10/31
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Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown etiology, characterized by inflammation of the symmetrical joints, multi-organ complications, flares and complete or partial remission periods, which results in disability and increased mortality. Methotrexate (MTX) remains the first-line therapy for active RA. In red blood cells (RBC) MTX is transformed into methotrexate polyglutamates (MTXPG). Disease activity and treatment results are strongly associated with methotrexate polyglutamate concentrations in red blood cells. The article presents the correlation between the route of administration of the treatment, RBC MTXPG concentration and disease activity in patients with rheumatoid arthritis. Also, the impact of genetic polymorphism in the folate-purine-pyrimidine pathway on effects of MTX therapy is stressed.
keywords:

rheumatoid arthritis, methotrexate, methotrexate polyglutamates







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