eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
Current issue Archive Manuscripts accepted About the journal Special issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
4/2020
vol. 16
 
Share:
Share:
more
 
 
Pharmacology and pharmacy
abstract:
Clinical research

Contribution to determining the antioxidant capacity of melatonin in orodispersible tablets – comparison with reference antioxidants

Herminia Muñoz
1
,
Sergio García
2
,
Adolfina Ruiz
1

1.
Pharmacy and Pharmaceutical Technology Department, School of Pharmacy, University of Granada, Granada, Spain
2.
Zoology Department, School of Science, University of Granada, Granada, Spain
Arch Med Sci 2020; 16 (4): 871–877
Online publish date: 2020/04/05
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
Melatonin is a hormone used in the treatment of diverse pathologies due to its ability to regulate numerous physiological processes related to biological rhythms and neuroendocrine function.

Material and methods
This study examines whether or not the antioxidant capacities of melatonin are modified during the creation of fast disintegrating oral tablets (FDDTs) through direct compression in which different concentrations of the active substance (3, 5, 10 and 60 mg) and excipients are made. In addition, the antioxidant capacity of melatonin is compared with that of reference antioxidants such as vitamin C, Trolox, resveratrol, glutathione and nicotinamide adenine dinucleotide phosphate (NADPH).

Results
Melatonin has a lower antioxidant capacity only 5% of the capacity of resveratrol. Resveratrol is the compound having the greatest antioxidant capacity. As for the influence of the tablets components, it was found that only at higher concentrations of melatonin (60 mg/tablet), with the excipients mannitol, polyvinylpyrrolidone (crospovidone), magnesium stearate and anhydrous colloidal silica, did a decrease occur in the antioxidant capacity value, possibly due to the lower percentage of these excipients in the formulation.

keywords:

melatonin, antioxidant, total antioxidative capacity, ferric ion reducing antioxidant power, fast dissolving/disintegrating tablets

Quick links
© 2020 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe