eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2016
vol. 41
 
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abstract:
Review paper

Coronins and their role in immunological phenomena

Beata Tokarz-Deptuła, Magdalena Malinowska, Mateusz Adamiak, Wiesław Deptuła

(Cent Eur J Immunol 2016; 41 (4): 435-441)
Online publish date: 2017/01/24
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Coronins are a large family of proteins occurring in many eukaryotes. In mammals, seven coronin genes have been identified, evidencing that coronins 1 to 6 present classic coronin structure, while coronin 7 is a tandem coronin particle, without a spiral domain, although the best characterised coronin, in terms of both structure and function, is the mammalian coronin 1. It has been proven that they are related to regulation of actin dynamics, e.g. as a result of interaction with the complex of proteins Arp2/3. These proteins also modulate the activity of immune system cells, including lymphocyte T and B cells, neutrophils and macrophages. They are involved in bacterial infections with Mycobacterium tuberculosis, M. leprae and Helicobacter pylori and participate in the response to viral infections, e.g. infections of lymphocytic choriomeningitis virus (LCMV) and vesicular stomatitis Indiana virus (VSV). Also their involvement in autoimmune diseases such as lupus erythematosus has been recorded.
keywords:

infections, coronins, immune system cells

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