Dermatofibroma (DF), also known as fibrous histiocytoma, is one of the most common cutaneous soft-tissue lesions, accounting for approximately 3% of skin lesion specimens received by dermatopathology laboratories. Dermatofibroma is a benign growth of oval cells in the dermis which resemble histiocytes and spindle cells that resemble fibroblasts. Clinically, DF can present as solitary, firm nodules to multiple papules with a relatively smooth surface. The aim of our study is to emphasize the crucial role of histopathology, which is the gold standard for diagnosis in suspicious and difficult cases, and sometimes requires the use of additional immunohistochemical staining.