Dermatology Review
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eISSN: 2084-9893
ISSN: 0033-2526
Dermatology Review/Przegląd Dermatologiczny
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6/2025
vol. 112
 
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abstract:
Case report

Cutaneous Metastases of Renal Cell Carcinoma Masquerading as Vascular Neoplasms: a Fatal Ruse

Sharath SM
1
,
Prachi Gole
1
,
Vijay D. Joshi
2
,
Sunanda Mahajan
1
,
Shreya Singh
1

  1. Department of Dermatology, Seth GS Medical College and KEM Hospital, Mumbai, India
  2. Fellow, Department of Dermatology, Seth GSMC/Medical College and KEM Hospital, Parel, Mumbai, India
Dermatol Rev/Przegl Dermatol 2025, 112, 392-396
DOI: https://doi.org/10.5114/dr.2025.160154
Online publish date: 2026/02/28
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Introduction
Cutaneous metastases from renal cell carcinoma are rare, with a reported prevalence of 2.8–6.3% of cases. These lesions can clinically mimic a wide range of infectious conditions, vascular proliferations, and adnexal tumors, including bacillary angiomatosis, pyogenic granuloma, Kaposi’s sarcoma, and eccrine acrospiroma.

Case report
A middle-aged man with a history of non-metastatic renal cell carcinoma, previously treated with nephrectomy, remained in remission during therapy with cabozantinib and lenvatinib. Abrupt discontinuation of targeted therapy was followed by the rapid development of angiomatous skin nodules after a prolonged disease-free interval. Initially interpreted as vascular tumors, the lesions were subsequently identified as cutaneous metastases of clear cell renal cell carcinoma. The patient deteriorated rapidly and died shortly thereafter.

Conclusions
This case highlights the importance of maintaining a high index of suspicion for cutaneous metastases in patients presenting with seemingly benign angiomatous skin lesions, particularly those with a history of renal cell carcinoma. Early diagnostic evaluation, including prompt skin biopsy, is essential to distinguish these lesions from their clinical mimics. Recognition of cutaneous metastases is crucial, as they represent a rare but grave prognostic indicator associated with poor outcomes in renal cell carcinoma.

keywords:

renal cell carcinoma, vascular tumors, cutaneous metastases, pyogenic granuloma



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