eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
Current issue Archive Manuscripts accepted About the journal Special issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
vol. 14
Systematic review/Meta-analysis

Descriptive epidemiology: prevalence, incidence, sociodemographic factors, socioeconomic domains, and quality of life of epilepsy: an update and systematic review

Seyed Shahabeddin Sadr, Javad Javanbakht, Abbas Norouzi Javidan, Majid Ghaffarpour, Safoura Khamse, Zeinab Naghshband

Arch Med Sci 2018; 14, 4: 717–724
Online publish date: 2016/06/07
View full text
Get citation
JabRef, Mendeley
Papers, Reference Manager, RefWorks, Zotero
The purpose of this study was to investigate the contributions of quality of life (QOL), sociodemographic factors (age, sex, etc.), residential areas, general attitudes toward epilepsy, socioeconomic domains, prevalence and incidence in epileptic patients from Iran.

Material and methods
A systematic literature search was conducted, including database searches in PubMed, Medline, Embase, ScienceDirect, Scopus, ISC, Health, Web of Science, and the Cochrane Library Database of relevant articles, personal files and systematic reviews to identify studies examining risk factors in epilepsy.

This review article shows that certain socio-demographic and socio-economic factors, geographic variation in epidemiologic patterns of epilepsy as well as clinical factors may be crucial in determining QOL in epilepsy patients and provides further evidence supporting the validity of the scale in QOL based on consideration of different target groups in different areas.

Prevalence of epilepsy appears to be correlated with socioeconomic status in the lower socioeconomic groups. Also demographic characteristics, socio-economic factors and clinical presentation are linked to different QOL of these patients among nations. The educational program has a beneficial effect on self-management behaviors in patients with epilepsy. More work needs to be done to improve tools that help to evaluate efficiently the health-related quality of life of people with epilepsy.


epilepsy, sociodemographic factors, socioeconomic status, prevalence, quality of life

Bell GS, Sander JW. The epidemiology of epilepsy: the size of the problem. Seizure 2001; 10: 306-14.
Ngugi AK, Bottomley C, Kleinschmidt I, Wagner RG, Kakooza-Mwesige A, Ae-Ngibise K. Prevalence of active convulsive epilepsy in subSaharan Africa and associated risk factors: cross-sectional and case-control studies. Lancet Neurol 2013; 4422: 1-11.
Murray CJ, Vos T, Lozano R, et al. Disabilityadjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380: 2197-223
World Health Organization. Epilepsy: epidemiology, aetiology and prognosis. Fact Sheet No. 165. WHO, Geneva.2001.
Belhocine M, de Boer H, Mandlhate C (eds.). Epilepsy in the WHO African Region: bridging the gap. World Health Organization, Geneva 2004.
Debrock C, Preux PM, Houinato D, Druet-Cabanac M, Kassa F, Adjien C. Estimation of the prevalence of epilepsy in the Benin region of Zinvie using the capture-recapture method. Int J Epidemiol 2000; 29: 330-5.
De Bittencourt PR, Adamolekum B, Bharucha N, et al. Epilepsy in the tropics: I. Epidemiology socioeconomic risk factors, and etiology. Epilepsia 1996; 37: 1121-7.
Preux PM, Druet-Cabanac M. Epidemiology and aetiology of epilepsy in sub-Saharan Africa. Lancet Neurol 2005; 4: 21-31.
Ngugi AK, Bottomley C, Kleinschmidt I, Sander, JW, Newton CR. Estimation of the burden of active andlife-time epilepsy: a meta-analytic approach. Epilepsia 2010; 51: 883-90.
Dayan PS, Lillis K, Bennett J, et al. Prevalence of and risk factors for intracranial abnormalities in unprovoked seizures. Pediatrics 2015; 136: e351-60.
Schaller B. Influences of brain tumor-associated pH changes and hypoxia on epileptogenesis. Acta Neurol Scand 2005; 111: 75-83.
Morgan CL, Ahmed Z, Kerr MP. Social deprivation and prevalence of epilepsy and associated health usage. J Neurol Neurosurg Psychiatry 2000; 69: 13-7.
Rodin E, Rennick P, Dennerll R, Lin Y. Vocational and educational problems of epileptic patients. Epilepsia 1972; 13: 149-60.
Darabi F. Assessment to results of integrated mental health program in primary health care system Chaharmahal Bakhtiari. Thesis in Master of Nursing, ShareKord University of Medical Sciences 2003; 24-6.
Nachvak M, Haghighat HR, Rezaei M. Prevalence and monitoring of retarded childs in Tehran at 2002. Quarterly of Science-Research Journal of Kermanshah University of Medical Sciences 2004; 3: 34-42.
Noorbala AA, Bagheri Yazdi SA, Yasamy MT, Mohammad K. Mental health survey of the adult 21. Population in Iran. Br J Psychiatry 2004; 184: 70-3.
Mohammadi M, Ghanizadeh A, Davidian H, Mohammadi M, Norouzian M. Prevalence of epilepsy and co morbidity of psychiatric disorders in Iran. Seizure 2006; 15: 476-82.
Pashapour A, Sadrodini A. Grandmal epilepsy and EEG variations in primary school children at Tabriz. Medical Journal of Tabriz University of Medical Sciences 2001; 50: 23-7.
Sayehmiri K, Tavan H, Sayehmiri F, Mohammadi I, Carson K. Prevalence of epilepsy in Iran: a meta-analysis and systematic review. Iran J Child Neurol 2014; 8: 9-17.
Forsgren, L. Prevalence of epilepsy in adults in northern Sweden. Epilepsia 1992; 33: 450-8.
Olafsson E, Hauser WA. Prevalence of epilepsy in rural Iceland: a population-based study. Epilepsia 1999; 40: 1529-34.
Birbeck GL, Kalichi EM. Epilepsy prevalence in rural Zambia: a door-to-door survey. Trop Med Int Health 2004; 9: 92-5.
Najafi MR, Rezaei F, Vakili Zarch N, Dehghani F, Barakatein M. Survey of pattern of personality and psychopathology in patients with Grandmal and complex partial epilepsy and comparison with control group. Journal of Shaheed Sadoughi University of Medical Sciences 2010; 2: 84-91.
Etemadifar M, Mirabdolbaghe P. Demographic and clinical characteristics of young epilepsy mortalities in Isfahan. Two quarterly of South Pediatric, Persian Golf Center of Health Researches in Boushehr University of Medical Sciences 2004; 2: 160-4.
Nasehi MM, Mahvalati Shamsabadi F, Ghofrani M. Associated factors in response to treatment in children with refractory epilepsy. J Babol University Med Sci 2010; 12: 61-6.
Kaheni S, Riyasi HR, Rezvani Kharashad MR, Sharifzadeh GH, Nakhaei S. Prevalence of epilepsy in children at primary schools and awareness of teachers about epilepsy at primary schools of Birjand at 2010. Novel Cares, Quarterly of Science Journal of Nursing and Midwifery in Birjand University of Medical Sciences 2011; 3: 135-42.
Newton CR. Epilepsy in poor regions of the world. Lancet 2012; 380: 1193-201.
Wilden JA, Cohen-Gadol AA. Evaluation of first nonfebrile seizures. Am Fam Phys 2012; 86: 334-40.
Shakirullah NA, Muhammad Nabi AKH. The prevalence, incidence and etiology of epilepsy. Int J Clin Exp Neurol 2014; 2: 29-39.
Inaloo S, Katibeh P. An epidemiologic study of 389 children with epilepsy in southern Iran. Iran J Child Neurol 2011; 5: 15-20.
Lisle JR, Waldron HA. Employees with epilepsy in the NHS. Br Med J 1986; 292: 305-6.
Callanghan N, Crowley M, Goggin T. Epilepsy and employment, marital, education and social status. Ir Med J
1992; 85: 17-9.
Hart YM, Shorvon SD. The nature of epilepsy in the general population. I. Characteristics of patients receiving medication for epilepsy. Epilepsy Res 1995; 21: 43-9.
Li X, Sundquist, J, Sundquist K. Socioeconomic and occupational risk factors for epilepsy: a nationwide epidemiological study in Sweden. Seizure 2008; 17: 254-60.
Begley C, Basu R, Lairson D, Reynolds T, Dubinsky S, Newmark M. Socioeconomic status, health care use, and outcomes: Persistence of disparities over time: disparities in epilepsy care and outcomes. Epilepsia 2011; 52: 957-64.
The relationship between the needs of patients with epilepsy and their quality of life in Society member’s patients in Iran. MSc thesis, Ministry of Health and Medical Education – Iran University of Medical Sciences and Health Services 1999.
Rajabi F, Dabiran S, Hatmi ZN, Zamani GR. Quality of life of epileptic patients compared to general population in Tehran. Acta Med Iran 2009; 47: 75-8.
Masoudnia E. Awareness, understanding and attitudes towards epilepsy among Iranian ethnic groups. Seizure 2009; 18: 369-73.
Ghanean H, Nojomi M, Jacobsson L. Public awareness and attitudes towards epilepsy in Tehran, Iran. Global Health Action 2013; 6: 21618.
Karimi N, Heidari M. Knowledge and attitudes toward epilepsy among school teachers in West of Iran. Iran
J Neurol 2015; 14: 130-5.
Asadi-Pooya AA, Torabi-Nami M. Knowledge and attitude towards epilepsy among biology teachers in Fars Province, Iran. Iran J Child Neurol 2012; 6: 13-8.
Stavem K, Loge JH, Kaasa S. Health status of people with epilepsy compared with a general reference population Epilepsia 2000; 41: 85-90.
Santhouse J, Carrier C, Arya S, Fowler H, Duncan S. A comparison of self-reported quality of life between patients with epilepsy and neurocardiogenic syncope. Epilepsia 2007; 48: 1019-22.
Berto P. Quality of life in patients with epilepsy and impact of treatments Pharmacoeconomics 2002; 15: 1039-59.
Austin JK, Boer H. Disruption in social functioning and services facilitating adjustment for the child and adult with epilepsy. In: Epilepsy: a comprehensive textbook. Engel J, Pedley T (eds.). Lippincott-Raven, Philadelphia 1997; 2191-201.
Wohlrab GC, Rinnert S, Bettendorf U, Fischbach H, Heinen G. Famoses: a modular educational program for children with epilepsy and their parents Epilepsy Behav 2007; 1: 44-8.
Yadegary MA, Maemodan FG, Nayeri ND, Ghanjekhanlo A. The effect of self-management training on health-related quality of life in patients with epilepsy. Epilepsy Behav 2015; 50: 108-12.
Baker GA, Jacoby A, Gorry J, Doughty J, Ellina V. Quality of life of people with epilepsy in Iran, the Gulf, and Near East. SIGN Group. Epilepsia 2005; 46: 132-40.
Darabi L, Montazeri A, Ebrahimi F, Vahdaninia M, Togha M. Clinical and demographic characteristics and quality of life in patients with epilepsy. Payesh J 2010; 9: 215-21.
Javaheri R, Neshat-Doost HT, Molavi H, Zare M. Efficacy of cognitive-behavioral stress management therapy on improving the quality of life in females with temporal lobe epilepsy. Arak Med Univ J 2010; 3: 32-43.
Aliasgharpour M, Dehgahn Nayeri N, Yadegary M, Haghani H. Effects of an educational program on self-management in patients with epilepsy. Seizure 2013; 22: 48-52.
Taylor J, Jacoby A, Baker GA, Marson AG. Self-reported and parent-reported quality of life of children and adolescents with new-onset epilepsy. Epilepsia 2011; 52: 1489-98.
Wu DY, Ding D, Wang Y, Hong Z. Quality of life and related factors in Chinese adolescents with active epilepsy. Epilepsy Res 2010; 90: 16-20.
Barbosa FD, Guerreiro MM, De Souza EA. The Brazilian version of the quality of life in epilepsy inventory for adolescents: translation, validity, and reliability. Epilepsy Behav 2008; 13: 218-22.
Riasi H, Rajabpour Sanati A, Ghaemi K. The stigma of epilepsy and its effects on marital status. Springerplus 2015; 3: 762.
Ebrahimi HA, Shafa MA, Hakimzadeh Asl S. Prevalence of active epilepsy in Kerman, Iran: a house based survey. Acta Neurol Taiwan 2012; 21: 115-24.
Talebi M, Farhoudi M, Godszad S, Abdollahi H, Talebi M, Aghili AR. Epidemiological study about the prevalence of the types of epilepsy in Tabriz city. Medical Journal of Tabriz University of Medical Sciences and Health Services 2014; 36: 60-5.
Zibaei M, Zinab Zamani Z, Chahichi Esfahani A, Anbari KH, Nazer MR. Toxoplasma infection and epilepsy: a case-control study in Iran. Neurol Asia 2011; 16: 299-302.
Asadi-Pooya AA, Nikseresht A, Yaghoubi E, Nei M. Physical injuries in patients with epilepsy and their associated risk factors. Seizure 2012; 21: 165-8.
Rezaei AA, Saeidi SH. The study of age and sex frequency of epilepsy and its relating factors in epileptic patients referred to Sina and Ghaem Hospital in Hamadan city, 1986-95. J Rehabil 2000; 1: 52-6.
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe