Folia Neuropathologica

Abstract

4/2025 vol. 63
Case report

Diagnostic difficulties in progressive multifocal leukoencephalopathy: a case report

Angelika Stapińska-Syniec 1
,
Michał Sobstyl 1
,
Katarzyna Kurowska 2
,
Albert Acewicz 3
,
Teresa Wierzba-Bobrowicz 3
  1. Department of Neurosurgery, Institute of Psychiatry and Neurology, Warsaw, Poland
  2. 2nd Department of Neurology, Institute Psychiatry and Neurology, Warsaw, Poland
  3. Department of Neuropathology, Institute Psychiatry and Neurology, Warsaw, Poland
Folia Neuropathol 2025; 63 (4): 420-425
DOI: https://doi.org/10.5114/fn.2025.156093
Online publish date: 2025/12/09
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Progressive multifocal leukoencephalopathy (PML) is a demyelination disease of the central nervous system (CNS) caused by viral infection with John Cunningham polyomavirus (JC virus, JCV). PML affects mainly patients with immunodeficiency. Since the diagnosis is often challenging, it requires the close cooperation of clinicians. Due to the lack of specific treatment of JCV infection leading to PML, the current treatment is based on reversing the immunosuppression. Here we present a case of a 58-year-old woman who was ultimately diagnosed with PML based on neuropathological analysis of stereotactic biopsy specimens

Keywords

progressive multifocal leukoencephalopathy (PML), John Cunningham virus (JCV), demyelination disease, stereotactic biopsy

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