Advances in Dermatology and Allergology
eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current Issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
Share:
Send email
Share:
Original paper

Different clinical phenotypes of nail abnormalities in patients with severe atopic dermatitis: a single-centre cross-sectional study

Przemysław Hałubiec
1, 2, 3
,
Jacek Szepietowski
4, 5
,
Anna Wojas-Pelc
1, 2
,
Andrzej K. Jaworek
1, 2

  1. Chair of Dermatology, Jagiellonian University Medical College, Krakow, Poland
  2. Department of Dermatology and Allergology, University Hospital, Krakow, Poland
  3. Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, Krakow, Poland
  4. Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine, Wroclaw University of Science and Technology, Wroclaw, Poland
  5. Department of Dermato-Venereology, 4th Military Hospital, Wroclaw, Poland
Adv Dermatol Allergol
DOI: https://doi.org/10.5114/ada.2026.160782
Online publish date: 2026/04/13
Article files
- Different.pdf  [0.27 MB]
- Different Supplementary material.pdf  [0.09 MB]
Get citation
 
 
1. Weidinger S, Novak N. Atopic dermatitis. Lancet 2016; 387: 1109-22.
2. Afshari M, Kolackova M, Rosecka M, et al. Unraveling the skin: a comprehensive review of atopic dermatitis, current understanding, and approaches. Front Immunol 2024; 15: 1361005.
3. Guttman-Yassky E, Renert-Yuval Y, Brunner PM. Atopic dermatitis. Lancet 2025; 405: 583-96.
4. Kim JP, Chao LX, Simpson EL, et al. Persistence of atopic dermatitis: a systematic review and meta-analysis. J Am Acad Dermatol 2016; 75: 681-87.e11.
5. Ramírez-Marín HA, Silverberg JI. Differences between pedia­tric and adult atopic dermatitis. Pediatr Dermatol 2022; 39: 345-53.
6. Paller AS, Kong HH, Seed P, et al. The microbiome in patients with atopic dermatitis. J Allergy Clin Immunol 2019; 143: 26-35.
7. Drucker AM, Wang AR, Li WQ, et al. The burden of atopic dermatitis: summary of a report for the National Eczema Association. J Invest Dermatol 2017; 137: 26-30.
8. Laughter MR, Maymone MBC, Mashayekhi S, et al. The glo-bal burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990–2017. Br J Dermatol 2021; 184: 304-9.
9. Ali F, Vyas J, Finlay AY. Counting the burden: atopic dermatitis and health-related quality of life. Acta Derm Venereol 2020; 100: adv00161.
10. Brunner PM, Silverberg JI, Guttman-Yassky E, et al. Increasing comorbidities suggest that atopic dermatitis is a systemic disorder. J Invest Dermatol 2017; 137: 18-25.
11. Thyssen JP, Halling AS, Schmid-Grendelmeier P, et al. Comorbidities of atopic dermatitis: what does the evidence say? J Allergy Clin Immunol 2023; 151: 1155-62.
12. de Berker D. Nail anatomy. Clin Dermatol 2013; 31: 509-15.
13. Haneke E. Functional, aesthetic, and procedural significance of the nail unit. In: Critical Thinking in Contemporary Dermatology: Cognitive Essays. Gupta S, Mehta N, Dudani P (eds.). Springer, Singapore 2024; 65-78.
14. Battista T, Scalvenzi M, Martora F, et al. Nail psoriasis: an updated review of currently available systemic treatments. Clin Cosmet Investig Dermatol 2023; 16: 1899-932.
15. Bloom A, Blanken B, Schlakman B, et al. A review of nail dystrophies for the practitioner. Adv Skin Wound Care 2020; 33: 20-6.
16. Elewski BE, Tosti A. Risk factors and comorbidities for onychomycosis: implications for treatment with topical therapy. J Clin Aesthet Dermatol 2015; 8: 38-42.
17. Cuschieri S. The STROBE guidelines. Saudi J Anaesth 2019; 13 (Suppl 1): S31-4.
18. Rothe MJ, Grant-Kels JM. Diagnostic criteria for atopic dermatitis. Lancet 1996; 348: 769-70.
19. Hanifin JM, Baghoomian W, Grinich E, et al. The Eczema Area and Severity Index: a practical guide. Dermatitis 2022; 33: 187-92.
20. Nowicki RJ, Trzeciak M, Kaczmarski M, et al. Atopic dermatitis. Interdisciplinary diagnostic and therapeutic recommendations of the Polish Dermatological Society, Polish Society of Allergology, Polish Pediatric Society and Polish Society of Family Medicine. Part I. Prophylaxis, topical treatment and phototherapy. Dermatol Rev 2019; 106: 354-74.
21. Nowicki RJ, Trzeciak M, Kaczmarski M, et al. Atopic dermatitis. Interdisciplinary diagnostic and therapeutic recommendations of the Polish Dermatological Society, Polish Society of Allergology, Polish Pediatric Society and Polish Society of Family Medicine. Part II. Systemic treatment and new therapeutic methods. Dermatol Rev 2019; 106: 475-85.
22. Wollenberg A, Kinberger M, Arents B, et al. European guideline (EuroGuiDerm) on atopic eczema: part I – systemic therapy. J Eur Acad Dermatol Venereol 2022; 36: 1409-31.
23. Wollenberg A, Kinberger M, Arents B, et al. European guideline (EuroGuiDerm) on atopic eczema – part II: non-systemic treatments and treatment recommendations for special AE patient populations. J Eur Acad Dermatol Venereol 2022; 36: 1904-26.
24. Landgraf AJ, Lee Y. Dimensionality reduction for binary data through the projection of natural parameters. J Multivar Anal 2020; 180: 104668.
25. Arslan Uku S, Demir B, Cicek D, et al. Assessment of nail findings in children with atopic dermatitis. Clin Exp Dermatol 2021; 46: 1511-7.
26. Chng WQ, Yew YW. Nail manifestations in atopic dermatitis: a systematic review. Int J Dermatol 2020; 59: 670-6.
27. Satasia M, Sutaria AH. Nail whispers revealing dermatolo­gical and systemic secrets: an analysis of nail disorders associated with diverse dermatological and systemic conditions. Cureus 2023; 15: e45007.
28. Muneer H, Sathe NC, Masood S. Nail psoriasis. In: StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL) 2025 [updated 2024 Mar 1; cited 2025 Aug 7]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559260/.
29. Jadhav VM, Mahajan PM, Mhaske CB. Nail pitting and onycholysis. Indian J Dermatol Venereol Leprol 2009; 75: 631-3.
30. Chung BY, Choi YW, Kim HO, et al. Nail dystrophy in patients with atopic dermatitis and its association with disease severity. Ann Dermatol 2019; 31: 121-6.
31. Jaworek AK, Mo¿d¿eñ K, Murawska A, et al. Atypical changes in the nail apparatus in a patient with atopic dermatitis: a clinical case report. Pediatr Med Rodz 2024; 20: 252-6.
32. Jaworek AK, Szafraniec K, Jaworek M, et al. The level of total immunoglobulin E as an indicator of disease grade in adults with severe atopic dermatitis. Pol Merkur Lekarski 2019; 47: 217-20.
33. Navarro-Triviño FJ, Vega-Castillo JJ, Ruiz-Villaverde R. Nail changes successfully treated with dupilumab in a patient with severe atopic dermatitis. Australas J Dermatol 2021; 62: e468-e9.
34. Li J, Zhang D, Dong S, et al. Dupilumab for atopic dermatitis with twenty-nail dystrophy: a case report. Clin Cosmet Investig Dermatol 2025; 18: 1187-90.
35. Zubek AE, Vesely MD. Onychodystrophy associated with dupilumab therapy for atopic dermatitis. JAAD Case Rep 2021; 7: 20-2.
36. Wallis MS, Bowen WR, Guin JD. Pathogenesis of onychoschizia (lamellar dystrophy). J Am Acad Dermatol 1991; 24: 44-8.
37. Colombo VE, Gerber F, Bronhofer M, et al. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy. J Am Acad Dermatol 1990; 23: 1127-32.
38. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 2013; 310: 2191-4.
Copyright: © 2026 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2026 Termedia Sp. z o.o.
Developed by Termedia.