Dermatology Review
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eISSN: 2084-9893
ISSN: 0033-2526
Dermatology Review/Przegląd Dermatologiczny
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without publication fees
2/2025
vol. 112
 
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abstract:
Review article

Disrupting the Itch-Scratch Cycle: Innovative Therapies for Prurigo Nodularis – a Comprehensive Review

Aleksandra Sikora
1
,
Kinga Sikora
2
,
Mateusz Nieczyporuk
3
,
Szymon Pucyło
4
,
Jan Pielaciński
5
,
Katarzyna Ceglarz
6
,
Gabriela Piotrowska
7
,
Martyna Skweres
1
,
Aleksander Rudnik
8

  1. National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland
  2. Faculty of Medicine, University of Rzeszow, Poland
  3. First Department of Internal Medicine, Bielański Hospital named after Father Jerzy Popiełuszko, Warsaw, Poland
  4. Miedzylesie Specialist Hospital, Warsaw, Poland
  5. Independent Public Specialist Western Hospital of St. John Paul II, Gordzisk Mazowiecki, Poland
  6. Praski Hospital of the Transfiguration of the Lord, Warsaw, Poland
  7. Central Clinical Hospital, Medical University of Warsaw, Poland
  8. LUX MED Sp. z o.o., Warsaw, Poland
Dermatol Rev/Przegl Dermatol 2025, 112, 83-92
DOI: https://doi.org/10.5114/dr.2025.153203
Online publish date: 2025/06/30
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Introduction:
Prurigo nodularis is a chronic dermatological condition characterized by intensely pruritic nodules, significantly impairing patients’ quality of life. Managing moderate to severe prurigo nodularis remains a challenge due to the limited availability of effective therapeutic options. This highlights the urgent need to develop and approve new treatment approaches to manage moderate to severe cases of prurigo nodularis effectively.

Objective:
The primary objective of this review is to collect data on the efficacy, safety, and potential side effects of new treatment options for prurigo nodularis.

Methods:
A comprehensive search of PubMed and ClinicalTrials databases was conducted using terms such as “prurigo nodularis”, “new treatment”, “trials”, and “emerging therapeutics”.

Conclusions:
Results reveal a new wave of targeted therapies addressing specific receptors and pathways, offering hope for improved disease management. While these advancements hold promise, further research is necessary to determine their long-term safety and effectiveness.

keywords:

biological therapy, dupilumab, prurigo


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