eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2020
vol. 45
 
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abstract:
Clinical immunology

Does adiponectin play a role in the pathogenesis of chronic spontaneous urticaria?

Katarzyna Adamczyk
1
,
Dominika Wcisło-Dziadecka
2
,
Martyna Zbiciak-Nylec
1
,
Ligia Brzezińska-Wcisło
1
,
Zenon Brzoza
3, 4

1.
Department of Dermatology, School of Medicine in Katowice, Medical University of Silesia, Poland
2.
Department of Skin Structural Studies, Chair of Cosmetology, School of Pharmacy with Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Poland
3.
Department of Internal Diseases, Allergology and Clinical Immunology, School of Medicine with Division of Dentistry in Zabrze, Medical University of Silesia, Poland
4.
Department of Internal Diseases with Division of Allergology, Institute of Medical Sciences, University of Opole, Poland
(Centr Eur J Immunol 2020; 45 (1): 56-59)
Online publish date: 2020/04/06
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Introduction
Chronic spontaneous urticaria constitutes an interdisciplinary problem and its pathogenesis is still a subject of debate. Overweight and hyperlipidemia are supposed to be related to chronic spontaneous urticaria. Fatty tissue can be the source of adipokines.

Aim of the study
To assess the potential role of adiponectin in chronic spontaneous urticaria pathogenesis.

Material and methods
The study included 52 chronic spontaneous urticaria patients and 43 healthy controls. The patients were divided into two subgroups: patients with wheals only, and patients with urticaria and an accompanying angioedema. The adiponectin concentration was measured in all studied subjects.

Results
No statistically significant difference in adiponectin level was determined between the studied groups and subgroups.

Conclusions
We are among the first to present the results of study to determine a possible role of adipokines in chronic spontaneous urticaria pathogenesis. We did not observe any difference in adiponectin level. In our opinion, it is necessary to conduct further analyses in this field.

keywords:

adiponectin, adipokines, chronic urticaria, metabolism, pathogenesis

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