eISSN: 2299-0054
ISSN: 1895-4588
Videosurgery and Other Miniinvasive Techniques
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
vol. 18
General surgery

Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis

Hongxia Li
Shaofang Zhang
Lin Lin
Sanjay Rastogi

Interventional Operating Room, Yantaishan Hospital, Yantai, Shandong, China
Department of Hepatology Ward I, Yantai Qishan Hospital, Shandong Province, Yantai, Shandong, China
Department of Urology, Hospital of Traditional Chinese and Western Medicine of Taizhou, Wenling, Zhejiang, China
Consultant, ESIC Model Hospital, Guwahati, Assam, India
Videosurgery Miniinv 2023; 18 (1): 31–41
Online publish date: 2022/11/02
View full text Get citation
PlumX metrics:
The main components of enteral immunonutrition (EIN) are -3 fatty acids, glutamine, arginine, and nucleotide, which primarily raises the immunity of the host and helps to reduce postoperative infections and non-infectious difficulties. Although the potential benefits of EIN are widely reported, some researchers did not find it to be of much help, and hence valid conclusions about its role are still unclear. Aim: To evaluate the role of enteral immunonutrition on patients undergoing surgery for gastric cancer (GC).

Material and methods
Appropriate articles were searched from the PubMed, Medline, and Central databases using the appropriate keywords as per the PRISMA guidelines. Randomized controlled trials, and retrospective, prospective, and open-label studies were included as per the predefined PICOS criteria. Demographic summary and event data for the effect of EIN on patients undergoing surgery for GC were extracted from the included studies.

Twelve randomized controlled clinical trials with a total of 10,422 gastric cancer patients were included. We found the odds ratio value of 0.23 (95% CI: 0.09–0.59). The results are heterogeneous with a 2 value of 2.77, a 2 value of 1707.96, a df value of 11, an I2 value of 99%, a z value of 3.04, and a p-value of less than 0.05. The risk ratio is 0.47 (95% CI: 0.29–0.77) with heterogeneity of 2 value of 0.73, 2 value of 1428.34, df value of 11, I2 value of 99%, z value of 2.99, and p-value < 0.05.

The present meta-analysis strongly commends the use of EIN to boost the immunity of gastric cancer (GC) patients undergoing gastrectomy.


gastric cancer, surgery, immunity, nutrition, gastrectomy, enteral immunonutrition

Quick links
© 2023 Termedia Sp. z o.o.
Developed by Bentus.