eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
2/2024
vol. 75
 
Share:
Share:
abstract:
Original paper

Downregulated lncRNA LINC00908 correlates with a poor prognosis and increasing malignancy of gastric cancer

Chunyue Zhang
1
,
Yanmin Zhang
2
,
Yan Wang
2

  1. Department of Oncology, Hengshui People’s Hospital, Hengshui, China
  2. Department of Neurosurgery, Hengshui People’s Hospital, Hengshui, China
Pol J Pathol 2024; 75 (2): 157-165
Online publish date: 2024/07/09
View full text Get citation
 
PlumX metrics:
Long non-coding RNA LINC00908 is a functional biomarker in regulating tumour progression. Its dysregulation in gastric cancer implies its potential functional role. Few studies have noted the functional role of LINC00908 in gastric cancer. The potential of LINC00908 to serve as a biomarker in gastric cancer was evaluated.

A total of 113 paired gastric cancer tissues and normal tissues were collected from patients with gastric cancer. LINC00908 levels were evaluated by polymerase chain reaction, and its significance in disease progression and patients’ prognosis was assessed.

In vitro, the function of LINC00908 in tumour-related cellular processes was evaluated with CCK8 and Transwell assay. Significant downregulation of LINC00908 was observed in gastric cancer and was negatively associated with disease development and overall survival of patients. LINC00908 showed significant inhibitory effects on the proliferation, migration, and invasion of gastric cancer cells.

Additionally, miR-627-3p was sponged by LINC00908 and therefore mediated the function of LINC00908 in gastric cancer cells. LINC00908 functioned as a prognostic biomarker and tumour suppressor of gastric cancer, providing a therapeutic target for gastric cancer.
keywords:

gastric cancer, lncRNA LINC00908, prognosis, progression, cell processes

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.