eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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3/2018
vol. 35
 
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abstract:
Original paper

ERAP1 and HLA-C*06 are strongly associated with the risk of psoriasis in the population of northern Poland

Marta Stawczyk-Macieja
,
Aneta Szczerkowska-Dobosz
,
Krzysztof Rębała
,
Magdalena Gabig-Cimińska
,
Roman J. Nowicki
,
Agnieszka Haraś
,
Lidia Cybulska
,
Ewa Kapińska

Adv Dermatol Allergol 2018; XXXV (3): 286-292
Online publish date: 2018/06/18
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Introduction
HLA-C*06 is a major psoriasis genetic risk marker. Recent reports have been focused on the role of different polymorphisms within genes involved in the functioning of the epidermal barrier and antigen processing in the pathogenesis of psoriasis. Data on the association between genetic variants of LCE3B_LCE3C, CSTA, ERAP1, ZAP70 and this dermatosis in the population from Eastern Europe are lacking.

Aim
To compare the association between known genetic risk markers and psoriasis in a cohort of northern Polish patients with psoriasis and healthy controls.

Material and methods
Based on previous studies’ results, five susceptibility loci: HLA-C, LCE3C_LCE3B, ERAP1, ZAP70 and CSTA were selected for genotyping in 148 patients with chronic plaque psoriasis and 146 healthy controls. Each patient with this disease was clinically assessed with the Psoriasis Area and Severity Index.

Results
The study population showed a significant association of psoriasis and a single nucleotide polymorphism in the ERAP1 – rs26653 (p = 3.11 × 10–5) and HLA-C*06 allele (p = 1.02 × 10–11) when compared with the control group. The presence of HLA-C*06 or rs26653 G allele significantly increased the risk of psoriasis by 2.4 times or twice, respectively. Carrying rs26653 C allele considerably decreased the risk of psoriasis by 1.5 times.

Conclusions
In the context of pathogenesis of psoriasis, our findings might give the evidence on disturbances in the proteolytic processing of N-terminal fragments of antigens presented via major histocompatibility complex class I to T cells.

keywords:

psoriasis, genetic polymorphism, genome-wide association studies

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