REVIEW PAPER
Effect of chronic High Intensity Interval Training on glycosylated haemoglobin in people with type 2 diabetes: a meta-analysis
 
More details
Hide details
1
University of Costa Rica, San Pedro Montes de Oca, Costa Rica
 
 
Submission date: 2021-02-26
 
 
Acceptance date: 2021-06-08
 
 
Publication date: 2021-09-28
 
 
Hum Mov. 2023;24(1):32-45
 
KEYWORDS
TOPICS
ABSTRACT
Type 2 diabetes is a chronic disease with an increasing prevalence all over the world. The treatment includes an integral intervention with medical treatment, healthy diet, and regular exercise. High Intensity Interval Training has been recently proposed as part of this treatment to improve glycaemic control. The aim of this meta-analysis is to determine the effect of High Intensity Interval Training on glycosylated haemoglobin in people with type 2 diabetes during at least 12 weeks of intervention. The search was performed in EBSCOHost, Web of Science, Scopus, PubMed, and EMBASE. A total of 250 records were obtained and 22 studies met the inclusion criteria to be meta-analysed. The results showed that High Intensity Interval Training could significantly lower glycosylated haemoglobin; in the sedentary control group, glycosylated haemoglobin significantly increased, making glycaemic control worse. The improvement of glycosylated haemoglobin with High Intensity Interval Training can be influenced by diet, intensity of the intervals, and age. There were some limitations because of lack of control group and appropriate information in some studies. An adequate prescription program should be developed by a qualified professional to ensure best results.
 
REFERENCES (50)
1.
Franz MJ, Evert AB. Medical nutrition therapy for diabetes mellitus and hypoglycemia of nondiabetic origin. In: Mahan LK, Raymond JL (eds.), Krause’s food & the nutrition care process. St. Louis: Elsevier; 2017; 586–618.
 
2.
Zatońska K, Basiak-Rasała A, Rózańska D, Karczewski M, Wołyniec M, Szuba A, et al. Changes in diabetes prevalence and corresponding risk factors – findings from 3- and 6-year follow-up of PURE Poland cohort study. BMC Public Health. 2020;20(1):843; doi: 10.1186/s12889-020-08970-5.
 
3.
Aguilar AY. Costa Rican people lose an average of 13.2 years of life because of diabetes [in Spanish]. 2018. Available from: https://amprensa.com/2018/09/c....
 
4.
Buresh R, Berg K. Exercise for the management of type 2 diabetes mellitus: factors to consider with current guidelines. J Sports Med Phys Fitness. 2018;58(4):510–524; doi: 10.23736/S0022-4707.17.06969-9.
 
5.
World Health Organization. Use of glycated haemoglobin (HbA1c) in the diagnosis of diabetes mellitus. Geneva: WHO; 2011. Available from: https://www.who.int/diabetes/p....
 
6.
Shrivastava A, Mishra P, Shrivastava N, Mishra S, Kumar V, Zaidi SNH, et al. Awareness of glycosylated haemoglobin (HbA1c) among type 2 diabetes mellitus patients in a diabetic clinic in urban Allahabad. HECS Int J Comm Health Med Res. 2018;4(2):61–64.
 
7.
Morgen EK, Naugler C. Inappropriate repeats of six common tests in a Canadian city: a population cohort study within a laboratory informatics framework. Am J Clin Pathol. 2015;144(5):704–712; doi: 10.1309/AJCPYXDAUS2F8XJY.
 
8.
Reynolds TM, Smellie WSA, Twomey PJ. Glycated haemoglobin (HbA1c) monitoring. BMJ. 2006;333(7568):586–588; doi: 10.1136/bmj.38947.627847.AE.
 
9.
Da Silva DE, Grande AJ, Roever L, Tse G, Liu T, Biondi-Zoccai G, et al. High-intensity interval training in patients with type 2 diabetes mellitus: a systematic review. Curr Atheroscler Rep. 2019;21(2):8; doi: 10.1007/s11883-019-0767-9.
 
10.
Wormgoor SG, Dalleck LC, Zinn C, Harris NK. Effects of high-intensity interval training on people living with type 2 diabetes: a narrative review. Can J Diabetes. 2017;41(5):536–547; doi: 10.1016/j.jcjd.2016.12.004.
 
11.
De Nardi AT, Tolves T, Lenzi TL, Signori LU, da Silva AMV. High-intensity interval training versus continuous training on physiological and metabolic variables in prediabetes and type 2 diabetes: a meta-analysis. Diabetes Res Clin Pract. 2018;137:149–159; doi: 10.1016/j.diabres.2017.12.017.
 
12.
Deguchi K, Enishi T, Sato N, Miura H, Fujinaka Y, Matsuhisa M, et al. Acute effect of fast walking on postprandial blood glucose control in type 2 diabetes. Diabetol Int. 2016;7(2):119–123; doi: 10.1007/s13340-015-0217-z.
 
13.
*Karstoft K, Winding K, Knudsen SH, Nielsen JS, Thomsen C, Pedersen BK, et al. The effects of free-living interval-walking training on glycemic control, body composition, and physical fitness in type 2 diabetic patients: a randomized, controlled trial. Diabetes Care. 2013;36(2):228–236; doi: 10.2337/dc12-0658.
 
14.
Jang JE, Cho Y, Lee BW, Shin ES, Lee SH. Effectiveness of exercise intervention in reducing body weight and glycosylated hemoglobin levels in patients with type 2 diabetes mellitus in Korea: a systematic review and meta-analysis. Diabetes Metab J. 2019;43(3):302–318; doi: 10.4093/dmj.2018.0062.
 
15.
Liu J-X, Zhu L, Li P-J, Li N, Xu Y-B. Effectiveness of high-intensity interval training on glycemic control and cardiorespiratory fitness in patients with type 2 diabetes: a systematic review and meta-analysis. Aging Clin Exp Res. 2019;31(5):575–593; doi: 10.1007/s40520-018-1012-z.
 
16.
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700; doi: 10.1136/bmj.b2700.
 
17.
Wallace BC, Lajeunesse MJ, Dietz G, Dahabreh IJ, Trikalinos TA, Schmid CH, et al. OpenMEE: intuitive, open-source software for meta-analysis in ecology and evolutionary biology. Methods Ecol Evol. 2017;8(8):941–947; doi: 10.1111/2041-210X.12708.
 
18.
Borenstein M, Higgins JPT, Hedges LV, Rothstein HR. Basics of meta-analysis: I2 is not an absolute measure of heterogeneity. Res Synth Methods. 2017;8(1):5–18; doi: 10.1002/jrsm.1230.
 
19.
DiaSys Diagnostic Systems. HbA1c calculator. Available from: https://www.hba1cnet.com/hba1c....
 
20.
Physiotherapy Evidence Database. PEDro scale. Available from: https://www.pedro.org.au/engli....
 
21.
RStudio Team. RStudio: integrated development for R. Boston: RStudio, Inc.; 2015. Available from: http://www.rstudio.com/.
 
22.
*Aguilera Eguía RA, Russell Guzmán JA, Soto Muñoz ME, Villegas González BE, Poblete Aro CE, Ibacache Palma A. Effect of high-intensity interval training on the reduction of glycosylated hemoglobin in type-2 diabetic adult patients [in Spanish]. Medwave. 2015;15(2):e6079; doi: 10.5867/medwave.2015.02.6079.
 
23.
*Ahmed AS, Ahmed MS, Mahmoud WS, Abdelbasset WK, Elnaggar RK. Effect of high intensity interval training on heart rate variability and aerobic capacity in obese adults with type 2 diabetes mellitus. Biosci Res. 2019;16(3):2450–2458.
 
24.
*Alvarez C, Ramirez-Campillo R, Martinez-Salazar C, Mancilla R, Flores-Opazo M, Cano-Montoya J, et al. Low-volume high-intensity interval training as a Therapy for type 2 diabetes. Int J Sports Med. 2016;37(9):723–729; doi: 10.1055/s-0042-104935.
 
25.
*Bellia A, Iellamo F, De Carli E, Andreadi A, Padua E, Lombardo M, et al. Exercise individualized by TRIMPi method reduces arterial stiffness in early onset type 2 diabetic patients: a randomized controlled trial with aerobic interval training. Int J Cardiol. 2017;248:314–319; doi: 10.1016/j.ijcard.2017.06.065.
 
26.
*Cassidy SA, Thoma C, Hallsworth K, Jakovljevic DG, Parikh J, Hollingsworth KG, et al. High intensity intermittent exercise reverses abnormal cardiac function in people with type 2 diabetes: an MRI/S study. In: Boulton AJM, Del Prato S, Thorens B, Roden M, Walker M, Tack CJ, et al. (eds.), Minutes of the 49th General Assembly of the European Association for the Study of Diabetes. Diabetologia. 2014;57(Suppl. 1):1–566; S258. Available from: https://link.springer.com/cont....
 
27.
*Cassidy S, Thoma C, Hallsworth K, Parikh J, Hollingsworth KG, Taylor R, et al. High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial. Diabetologia. 2016;59(1):56–66; doi: 10.1007/s00125-015-3741-2.
 
28.
*Cassidy S, Vaidya V, Houghton D, Zalewski P, Seferovic JP, Hallsworth K, et al. Unsupervised high-intensity interval training improves glycaemic control but not cardiovascular autonomic function in type 2 diabetes patients: a randomised controlled trial. Diab Vasc Dis Res. 2019;16(1):69–76; doi: 10.1177/1479164118816223.
 
29.
*Francois ME, Durrer C, Pistawka KJ, Halperin FA, Chang C, Little JP. Combined interval training and post-exercise nutrition in type 2 diabetes: a randomized control trial. Front Physiol. 2017;8:528; doi: 10.3389/fphys.2017.00528.
 
30.
*Hollekim-Strand SM, Bjørgaas MR, Albrektsen G, Tjønna AE, Wisløff U, Ingul CB. High-intensity interval exercise effectively improves cardiac function in patients with type 2 diabetes mellitus and diastolic dysfunction: a randomized controlled trial. J Am Coll Cardiol. 2014;64(16):1758–1760; doi: 10.1016/j.jacc.2014.07.0971.
 
31.
*Hua L, Lei M, Xue S, Li X, Li S, Xie Q. Effect of fish oil supplementation combined with high-intensity interval training in newly diagnosed non-obese type 2 diabetes: a randomized controlled trial. J Clin Biochem Nutr. 2020;66(2):146–151; doi: 10.3164/jcbn.19-64.
 
32.
*Macías-Cervantes MH, Casillas LG, Sevilla MA, Figueroa A, Zarate E, Guerrero GA. Metabolic changes after two differents exercise programs in sedentary type 2 diabetic patients. Med Sci Sports Exerc. 2017;49(5S):1020; doi: 10.1249/01.mss.0000519799.35679.86.
 
33.
*Magalhães JP, Júdice PB, Ribeiro R, Andrade R, Raposo J, Dores H, et al. Effectiveness of high-intensity interval training combined with resistance training versus continuous moderate-intensity training com bined with resistance training in patients with type 2 diabetes: a one-year randomized controlled trial. Diabetes Obes Metab. 2019;21(3):550–559; doi: 10.1111/dom.13551.
 
34.
*Mangiamarchi P, Caniuqueo A, Ramírez-Campillo R, Cárdenas P, Morales S, Cano-Montoya J, et al. Effects of high-intensity interval training and nutritional education in patients with type 2 diabetes [in Spanish]. Rev Med Chile. 2017;145(7):845–853; doi: 10.4067/s0034-98872017000700845.
 
35.
*Maillard F, Rousset S, Pereira B, Traore A, de Pradel Del Amaze P, Boirie Y, et al. High-intensity interval training reduces abdominal fat mass in postmenopausal women with type 2 diabetes. Diabetes Metab. 2016;42(6):433–441; doi: 10.1016/j.diabet.2016.07.031.
 
36.
*Mir E, Moazzami M, Bijeh N, Hakak Dokht E, Rahimi N. Changes in SFRP5, WNT5A, HbA1c, BMI, PBF, and insulin resistance in men with type 2 diabetes after 12 weeks of combined exercise (HIIT and resistance). Int J Diabetes Dev Ctries. 2020;40(2):248–254; doi: 10.1007/s13410-019-00790-7.
 
37.
*Mitranun W, Deerochanawong C, Tanaka H, Suksom D. Continuous vs interval training on glycemic control and macro- and microvascular reactivity in type 2 diabetic patients. Scand J Med Sci Sports. 2014;24(2):e69–e76; doi: 10.1111/sms.12112.
 
38.
*Støa EM, Meling S, Nyhus L-K, Strømstad G, Mangerud KM, Helgerud J, et al. High-intensity aerobic interval training improves aerobic fitness and HbA1c among persons diagnosed with type 2 diabetes. Eur J Appl Physiol. 2017;117(3):455–467; doi: 10.1007/s00421-017-3540-1.
 
39.
*Sudarsono NC, Tulaar ABM, Jusman SWA, Soewondo P, Sudaryo MDK, Siagian M, et al. The effects of combined high-intensity interval and resistance training on glycemic control and oxidative stress in T2DM. Asian J Sports Med. 2019;10(3):e91841; doi: 10.5812/asjsm.91841.
 
40.
*Terada T, Friesen A, Chahal BS, Bell GJ, McCargar LJ, Boulé NG. Feasibility and preliminary efficacy of high intensity interval training in type 2 diabetes. Diabetes Res Clin Pract. 2013;99(2):120–129; doi: 10.1016/j.diabres.2012.10.019.
 
41.
*Way KL, Sabag A, Sultana RN, Baker MK, Keating SE, Lanting S, et al. The effect of low-volume high-intensity interval training on cardiovascular health outcomes in type 2 diabetes: a randomised controlled trial. Int J Cardiol. 2020;320:148–154; doi: 10.1016/j.ijcard.2020.06.019.
 
42.
*Wormgoor SG, Dalleck LC, Zinn C, Borotkanics R, Harris NK. High-intensity interval training is equivalent to moderate-intensity continuous training for shortand medium-term outcomes of glucose control, cardiometabolic risk, and microvascular complication markers in men with type 2 diabetes. Front Endocrinol. 2018;9:475; doi: 10.3389/fendo.2018.00475.
 
43.
American College of Sports Medicine. ACSM’s guidelines for exercise testing and prescription, 10th ed. Philadelphia: Wolters Kluwer; 2018.
 
44.
Lora-Pozo I, Lucena-Anton D, Salazar A, Galán-Mercant A, Moral-Munoz JA. Anthropometric, cardiopulmonary and metabolic benefits of the high-intensity interval training versus moderate, low-intensity or control for type 2 diabetes: systematic review and meta-analysis. Int J Environ Res Public Health. 2019;16(22):4524; doi: 10.3390/ijerph16224524.
 
45.
Afrasyabi S, Marandi SM, Kargarfard M. The effects of high intensity interval training on appetite management in individuals with type 2 diabetes: influenced by participants weight. J Diabetes Metab Disord. 2019;18(1):107–117; doi: 10.1007/s40200-019-00396-0.
 
46.
Mottalib A, Salsberg V, Mohd-Yusof B-N, Mohamed W, Carolan P, Pober DM, et al. Effects of nutrition Therapy on HbA1c and cardiovascular disease risk factors in overweight and obese patients with type 2 diabetes. Nutr J. 2018;17(1):42; doi: 10.1186/s12937-018-0351-0.
 
47.
Peng XV, Ayyagari R, Lubwama R, Shi L, Price-Haywood EG, Hollander P, et al. Impact of simultaneous versus sequential initiation of basal insulin and glucagon-like peptide-1 receptor agonists on HbA1c in type 2 diabetes: a retrospective observational study. Diabetes Ther. 2020;11(4):995–1005; doi: 10.1007/s13300-020-00783-4.
 
48.
Abusaib M, Ahmed M, Nwayyir HA, Alidrisi HA, Al-Abbood M, Al-Bayati A, et al. Iraqi experts consensus on the management of type 2 diabetes/prediabetes in adults. Clin Med Insights Endocrinol Diabetes. 2020;13:1–11; doi: 10.1177/1179551420942232.
 
49.
Devitskaya D, Villalobos C, VanNess JM, Vosti PD, King AC, Jensen CD. Sex-specific HbA1c responses to structured exercise among patients with type 2 diabetes. Med Sci Sports Exerc. 2019;51(6S):299–300; doi: 10.1249/01.mss.0000561405.06744.80.
 
50.
Montes de Oca García A, Gutiérrez Manzanedo J, Ponce González JG. High-intensity interval training (HIIT) as a therapeutic tool in patients with type 2 diabetes mellitus: a narrative review [in Spanish]. Retos. 2019; 36(2):633–639; doi: 10.47197/retos.v36i36.69762.
 
eISSN:1899-1955
Journals System - logo
Scroll to top