ISSN: 1899-1955
Human Movement
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2/2014
vol. 15
 
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abstract:
Original paper

Effects of l-arginine supplementation on blood pressure reduction pre-, peri-, and post-cardiovascular stimulus in hypertensive subjects with different angiotensin-converting-enzyme genotypes

Carlos Ricardo Maneck Malfatti
,
João Luiz Lang Pavlak
,
Luiz Augusto Da Silva
,
Thiago Emannuel Medeiros
,
Katia Cristina Alonso
,
Roberto Ferreira Artoni
,
Viviane Nogaroto
,
Janaína Angela Túrmina
,
Ana Osiecki
,
Raul Osiecki

Online publish date: 2018/04/19
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Purpose
The present study investigated whether L-arginine supplementation reduces blood pressure (BP) in hypertensive subjects with different ACE genotypes.

Methods
Eight male hypertensive patients received L-arginine (2 or 4 g/day) or a placebo for a period of 4 days prior an exercise test. Statistical analysis consisted of one-way analysis of variance.

Results
L-arginine supplementation induced a statistically significant (p > 0.05) reduction in systolic BP measured during rest (reductions of 7.8% and 12.3% with 2 and 4 g/day, respectively), exercise (reductions of 11.8% and 10.4% with 2 and 4 g/day, respectively), and recovery (reductions of 11.7% and 10.7% with 2 and 4 g/day, respectively). The observed magnitude of BP reduction suggests an association with ACE polymorphism; a larger effect was seen with the II and DI genotypes compared with the DD genotype (II: 121 mmHg and DI: 133 mmHg vs. DD: 144 mmHg).

Conclusions
The results showed that L-arginine supplementation at low doses was efficient in reducing BP and that vasodilator actions that occurred through the secretion of nitric oxide might be ACE genotype dependent.

keywords:

exercise; hypertension; nitric oxide; vasodilatation

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