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Archives of Medical Science
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vol. 15
 
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abstract:
Systematic review/Meta-analysis

Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis

Man Jin, Yali Mo, Kaisheng Ye, Mingxian Chen, Yi Liu, Cao He

Arch Med Sci 2019; 15, 1: 23–32
Online publish date: 2017/07/31
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Introduction
Functional dyspepsia (FD) is typically treated with serotonin receptor (5-HT) agonists such as cisapride, mosapride, tegaserod and tandospirone citrate. However, there are conflicting efficacy data, possibly due to significant heterogeneity between studies. In this meta-analysis, we analyzed the efficacy and safety data from studies evaluating the efficacy of serotonin receptor agonists in patients with FD.

Material and methods
Relevant studies were selected from the Medline, Cochrane, EMBASE, and Google Scholar databases. The meta-analysis included 10 RCTs which evaluated the efficacy of serotonin receptor agonists in patients with FD (final total of 892 patients in the serotonin receptor agonist group, and 640 participants in the placebo group). The primary outcomes were the response rates and abdominal symptoms score. The Cochrane Collaboration’s tool was used to assess risk. Sensitivity analysis was carried out using the leave-one-out approach.

Results
Patients treated with serotonin receptor agonists had a significantly higher response rate compared to placebo-treated patients (pooled OR = 2.99; 95% CI: 1.15–7.77; p = 0.025). Patients treated with serotonin receptor agonists had a significant improvement in symptom scores compared to the placebo group (pooled standardized mean difference = –0.43; 95% CI: –0.83 to –0.04; p = 0.031). Sensitivity analysis indicated that the pooled estimates for abdominal symptom score might be affected by the Yeoh et al. (1997) study.

Conclusions
Serotonin receptor agonists had a significantly higher efficacy compared to placebo in the treatment of FD.

keywords:

functional dyspepsia, serotonin receptor, efficacy, placebo, meta-analysis

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