eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
Current issue Archive Manuscripts accepted About the journal Special issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
1/2020
vol. 16
 
Share:
Share:
more
 
 
abstract:
Clinical research

Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes

Aleksandra Klisic
1
,
Nebojsa Kavaric
1
,
Verica Stanisic
2
,
Sanja Vujcic
3
,
Vesna Spasojevic-Kalimanovska
3
,
Ana Ninic
3
,
Jelena Kotur-Stevuljevic
3

1.
Center of Laboratory Diagnostics, Primary Health Care Center, Podgorica, Montenegro
2.
Department of Radiology, Clinical Center of Montenegro, Podgorica, Montenegro
3.
Department of Medical Biochemistry, University of Belgrade – Faculty of Pharmacy, Belgrade, Serbia
Arch Med Sci 2020; 16 (1): 42–50
Online publish date: 2019/08/27
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
We aimed to examine serum endocan level and the summary involvement of dyslipidemia, oxidative stress (OS) and inflammation by calculation of its comprehensive score (i.e. Dyslipidemia-Oxy-Inflammation (DOI) score) in relation to glucoregulation in subjects with prediabetes and overt type 2 diabetes (T2D).

Material and methods
A total of 59 patients with prediabetes and 102 patients with T2D were compared with 117 diabetes-free controls. Glycated hemoglobin (HbA1c), inflammation, OS and lipid parameters were measured. Associations of clinical data with HbA1c level were tested with univariate and multivariate logistic ordinal regression analysis. HbA1c as a dependent variable is given at the ordinal level (i.e. < 5.7%; 5.7–6.4%, > 6.4%, respectively).

Results
Endocan was significantly higher in the T2D group than in the controls. As endocan concentration rose by 1 unit, the probability for higher HbA1c concentration increased by more than 3 times (OR = 3.69, 95% CI: 1.84–7.01, p < 0.001). Also, a rise in the dyslipidemia score, oxy score, inflammation score and DOI score by 1 unit increased the probability of higher HbA1c concentration by 19%, 13%, 51% and 11%, respectively. In the models, after adjustment for confounding variables, endocan and DOI score remained independent predictors of HbA1c level.

Conclusions
Endocan and DOI score are independently correlated with HbA1c in patients with prediabetes and overt T2D.

keywords:

inflammation, diabetes, oxidative stress, glycemic control, endocan

Quick links
© 2020 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe