Abstract
1/2021
vol. 72
Letter to the Editor
Endometrial adenocarcinoma with gastrointestinal differentiation – a newly described entity, with morphologic diversity
- Department of Pathology, University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania
- Department of Cardiology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Romania
- Department of Pathology, Emergency Hospital, Targu Mures, Romania
- Department of Gynecology and Obstetrics, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Romania
Pol J Pathol 2021; 72 (1): 84-86
Online publish date: 2021/05/31
Gastrointestinal type of endometrial carcinoma is a newly described entity for which clearly defined diagnostic criteria have only recently been published. Among morphologic criteria, gastrointestinal mucinous adenocarcinoma of endometrium must not show a typical endometrioid component. We present a case with morphologic diversity, with areas showing gastric and intestinal differentiation as well as an endometrioid-like component. However, the endometrioid-like component not only did not show classic squamous metaplasia, but was also MUC6-positive, while the positivity for ER/PR was only focal. The recognition of gastric/gastrointestinal differentiation in endometrial carcinomas is best accomplished using both morphology and immunohistochemistry rather than either alone.
Keywords
endometrial carcinoma, gastrointestinal differentiation, morphology
Integrated with
