RESEARCH PAPER
Evaluation of correlation between ocular manifestations with CD4+ count in HIV patients: a cross-sectional study
 
 
 
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Department of Ophthalmology, Vydehi Medical College and Research Center, Bangalore, India
 
 
Submission date: 2020-12-30
 
 
Final revision date: 2021-03-21
 
 
Acceptance date: 2021-03-21
 
 
Publication date: 2021-12-26
 
 
HIV & AIDS Review 2021;20(4):264-269
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
With the introduction of highly active antiretroviral therapy (HAART), improved quality of life and reduced mortality in human immunodeficiency virus (HIV)-infected population have increased. The importance of visual acuity, in any individual is obvious, and heightened importance in those afflicted by disorders is even more crucial. In this context, this study reports details of a comprehensive ocular evaluation in a HIV population, and its’ correlation with severity of the disease. The aim of the study was to determine the incidence of ocular manifestation and correlate CD4+ count levels, with incidence of ocular manifestations in HIV-positive patients.

Material and methods:
This was a cross-sectional study that evaluated ophthalmic manifestations in patients diagnosed with HIV infection in an urban ophthalmological center. Detailed ophthalmological examination was conducted. Various parameters of the disease and severity of HIV were estimated and correlated with ophthalmological findings.

Results:
In 2 years, 300 HIV-positive (229 males) patients, mostly aged between 30 and 40 years, were assessed. 69 (23%) patients were found to have ocular manifestation, 73.9% were in the range of 0-5 years of HIV duration, 28 (9.3%) patients presented with anterior segment and 62 (26.6%) with posterior segment pathology, like HIV retinopathy. Cytomegalovirus retinitis poor visual acuity was observed in females (20.5%), aged 0-35 years, with HIV duration of 0-5 years and CD4+ count less than 200.

Conclusions:
The focus on a comprehensive ocular evaluation, irrespective of visual acuity and possibility of improvement in ocular follow-up of HIV-infected patients needs to be emphasized.

 
REFERENCES (14)
1.
Global HIV and AIDS statistics – 2020 fact sheet UNAIDS. Available from: https://www.unaids.org/en/reso...% 20million%20%5B24.5%20million%E2%80%9325.6,infected%20with%20HIV%20in%202019 (Accessed: 24.11.2020).
 
2.
HIV and AIDS in India. Available from: https://www.avert.
 
3.
org/professionals/hiv-around-world/asia-pacific/india (Accessed: 24.11.2020).
 
4.
District HIV/AIDS Epidemiological Profiles developed through Data Triangulation. Fact Sheets. Karnataka State. Available from: http://www.naco.gov.in/sites/d... (Accessed: 24.11.2020).
 
5.
Retinal manifestations of the Acquired immunodeficiency syndrome: Diagnosis and Treatment. In: Albert DM, Miller JW, Azar DT, Young LH (eds.). Albert and Jackobiec’s Principles and Practice of Ophthalmology. 3rd ed. Elsevier, p. 2095.
 
6.
Joshi KA, Patel N, Kalita K, et al. Evaluation of fundoscopic findings in HIV positive patients in relation to HARRT and CD4 count. Delhi J Ophthalmol 2018; 29: 34-38.
 
7.
Sudharshan S, Nair N, Curi A, Banker A, Kempen JH. Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy – an update. Indian J Ophthalmol 2020; 68: 1787-1798.
 
8.
Munro M, Yadavalli T, Fonteh C, Arfeen S, Lobo-Chan AM. Cytomegalovirus retinitis in HIV and non-HIV individuals. Microorganisms 2019; 8: 55.
 
9.
Hothi HS, Gohil NR, Parekh NV, Patel SS. A prevalence study of ocular manifestations in HIV positive patients on highly active anti-retroviral therapy. Int J Community Med Public Health 2019; 6: 2950-2954.
 
10.
Sudharshan S, Kaleemunnisha S, Banu AA, et al. Ocular lesions in 1,000 consecutive HIV-positive patients in India: a long-term study.J Ophthalmic Inflamm Infect 2013; 3: 2.
 
11.
Bekele S, Gelaw Y, Tessema F. Ocular manifestation of HIV/AIDS and correlation with CD4+ cells count among adult HIV/AIDS patients in Jimma town, Ethiopia: a cross sectional study. BMC Ophthalmol 2013; 13: 20.
 
12.
Shah SU, Kerkar SP, Pazare AR. Evaluation of ocular manifestations and blindness in HIV/AIDS patients on HAART in a tertiary care hospital in western India. Br J Ophthalmology 2009; 93: 88-90.
 
13.
Jabs DA, Van Natta ML, Holbrook JT, Kempen JH, Meinert CL, Davis MD; Studies of the Ocular Complications of AIDS Research Group. Longitudinal study of the ocular complications of AIDS: 2. Ocular examination results at enrollment. Ophthalmology 2007; 114: 787-793.
 
14.
who.int2020. Tuberculosis and HIV [online]. Available at: https://www.who.inthiv/topics/... [Accessed: 21.12.2020].
 
eISSN:1732-2707
ISSN:1730-1270
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