eISSN: 2449-8580
ISSN: 1734-3402
Family Medicine & Primary Care Review
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2/2024
vol. 26
 
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abstract:
Original paper

Evaluation of pro-oxidant antioxidant balance (PAB) in infants with respiratory distress syndrome (RDS) and their mothers compared to normal cases

Faezeh Ghasemi
1
,
Maryam Shokrpour
2
,
Hasan Solhi
3
,
Hassan Taherahmadi
4

  1. Blood Transfusion Research Centre, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
  2. Department of Gynaecology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
  3. Department of Forensic Medicine and Toxicology, Arak University of Medical Sciences, Arak, Iran
  4. Department of Paediatrics, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
Family Medicine & Primary Care Review 2024; 26(2): 184–187
Online publish date: 2024/06/17
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Background
Oxidative stress plays a key role in respiratory distress syndrome (RDS) in neonates. The pro-oxidant antioxidant balance (PAB) assay is a reliable and accurate method for determination of serum oxidants and antioxidants.

Objectives
Determination of the pro-oxidant antioxidant balance in preterm infants suffering from infant RDS and their mothers as patients in comparison with full-term infants and their mothers as normal controls.

Material and methods
The study was conducted on 54 neonates with infant RDS (sera pH < 7.2, Apgar score ≤ 5 and serious signs of RDS) and their mothers (n = 54), and the controls included 40 full-term infants (abnormal clinical sign were not seen until three days after delivery) and their mothers (n = 40). The samples were obtained from the infants’ cord blood and mothers’ venous blood immediately after delivery. The PAB assay was preformed on the subject's sera using a simple, rapid, and accurate method.

Results
The PAB values of preterm infants with respiratory distress syndrome and their mothers and the full-term normal controls and their mothers were (34 ± 21), (14 ± 8.1), (183 ± 29.3) and (174 ± 18.9), respectively. Our obtained results have demonstrated that the PAB level is significantly higher in infants suffering from RDS than that of normal infant (p < 0.01). SPSS version 16 was used for statistical analysis, based on the one-way ANOVA test. A p-value < 0.05 was considered statistically significant.

Conclusions
The PAB level of infants suffering from RDS and their mothers is significantly higher than those of the control group with a normal full-term delivery.

keywords:

oxidative stress, respiratory distress syndrome, infant

 
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