eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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abstract:
Clinical research

Evaluation of selected parameters of the coagulation system during the perioperative period in patients undergoing endoscopic surgery of the paranasal sinuses

Joanna Urbaniak
,
Kalina Owczarek
,
Jarosław Miłoński
,
Piotr Pietkiewicz
,
Anna Jałocha-Kaczka
,
Jurek Olszewski

Arch Med Sci
Online publish date: 2018/01/04
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Introduction: The aim of the study was to evaluate selected parameters of the coagulation system during the perioperative period in patients undergoing endoscopic sinus surgery.

Material and methods: The study involved 121 patients: group I – 42 patients who did not receive anticoagulatory or antiplatelet medications, qualified for endoscopic sinus surgery under total intravenous anaesthesia (TIVA); group II – 40 patients who received in the perioperative period low-molecular-weight heparins, qualified for endoscopic sinus surgery under TIVA; group III – 39 patients diagnosed according to a schedule, due to vertigo or loss of hearing. All the patients received a full laryngological examination and detailed audiological and otoneurological diagnostics, and examination of selected haemostatic parameters before the surgery/diagnostics.

Results: The analysis of concentrations of coagulation parameters in groups I and II revealed a statistically significantly higher international normalized ratio value before surgery (I – 1.11; II – 1.08) and 48 h following surgery (I – 1.15; II – 1.10) in group I. The concentration of coagulation factor VII in the study patients was considerably higher in group I for all three measurements (481.93; 443.13; 486.02). The concentration of fibrinogen (coagulation factor I) was significantly lower in group I before surgery (3.2) and at 6 h after surgery (2.84). A significantly lower level of von Willebrand factor was found in group I before surgery (2.94). Comparing test results of groups I and III, who did not receive antiaggregants, statistically significant differences were observed in both tests for factors VII and VIII.

Conclusions: Concentrations of von Willebrand factor and prothrombin revealed statistically significant differences in between groups.
keywords:

intranasal surgery, low-molecular-weight heparin, antiplatelet drugs, blood coagulation factors, intravenous anaesthesia

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