eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
5/2020
vol. 37
 
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abstract:
Original paper

Evaluation of the effects of hair colouring products on the oxidative status in rats

Hülya Nazik
1
,
Duygun Altintaş Aykan
2
,
Muhammed Seyithanoğlu
3
,
Perihan Öztürk
1
,
Mehmet Kamil Mülayim
1
,
Hakan Nazik
4

1.
Department of Dermatology, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey
2.
Department of Pharmacology, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey
3.
Department of Biochemistry, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey
4.
Department of Obstetrics and Gynecology, Adana Numune Education and Research Hospital, Adana, Turkey
Adv Dermatol Allergol 2020; XXXVII (5): 766-770
Online publish date: 2020/11/07
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Introduction
Permanent hair dyes, oxidant creams, and henna are usually used for cosmetic purposes and sometimes for therapeutic expectations. The effects of these products, which are used to change hair colour and can be absorbed percutaneously on the oxidative status is not known exactly.

Aim
To investigate the effects of these products, which have various contents, on the oxidative status using an in vivo rat model.

Material and methods
The products used for hair colouring were prepared as recommended for human use and applied to the back region of Wistar albino rats. Superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione peroxidase (GSH-Px) levels were measured in serum and liver samples of rats. The Kruskal-Wallis test showed significant differences in serum SOD, aspartate aminotranspherase (AST), alanine aminotranspherase (ALT), and liver MDA levels among the study groups.

Results
There were statistically significant positive correlations between hepatic MDA values and AST and ALT values. Hair dyes, oxidant creams, and henna were found to have oxidative and hepatotoxic effects. Surprisingly, comparisons revealed that oxidative effect and hepatic toxicity of the oxidant cream and henna were similar. The oxidant cream was more oxidating and hepatotoxic than the hair dye.

Conclusions
Knowing the facts about these products, which are easily accessible to every individual in society and are considered to be innocent, will prevent possible harm.

keywords:

hair dye, henna, hepatotoxicity, oxidant cream, oxidative stress

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