eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
1/2017
vol. 42
 
Share:
Share:
abstract:
Case report

Exceptional manifestation of polyautoimmunity in a very young girl – a case report

Agnieszka Mroczkowska-Juchkiewicz
,
Jacek Postępski
,
Edyta Olesińska
,
Paulina Krawiec
,
Elżbieta Pac-Kożuchowska

(Cent Eur J Immunol 2017; 42 (1): 107-110)
Online publish date: 2017/05/08
View full text Get citation
 
PlumX metrics:
Polyautoimmunity is defined as the presence of more than one autoimmune disease in a single patient. The exact pathogenic mechanisms responsible for the coexistence of distinct autoimmune diseases within an individual have not been clearly explained. We report a case of a very young girl with the extremely rare co-existence of four distinct autoimmune diseases i.e. juvenile idiopathic arthritis, type 1 diabetes mellitus, coeliac disease and autoimmune hepatitis, recognized based on validated international classification criteria. The best to our knowledge there has been no case reporting coexistence of these particular four disorders in an individual. Moreover, all these diseases occurred during first three years of life, which also cause that case unique. Molecular studies of human leukocyte antigen (HLA) class II in our patient showed the presence of the HLA DRB1*01, HLA DRB1*03, HLA DQB1*02, HLA DQB1*05 molecules, which may suggest immunogenetic links between those autoimmune diseases. The presented case highlights the importance of active screening for other autoimmune diseases, if a patient with one autoimmune disease manifests with new or nonspecific symptoms.
keywords:

juvenile idiopathic arthritis, autoimmune hepatitis, celiac disease, type 1 diabetes, polyautoimmunity

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.