eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2014
vol. 39
 
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abstract:

Experimental immunology
A novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid arthritis patients

Yuki Nanke
,
Toru Yago
,
Tsuyoshi Kobashigawa
,
Manabu Kawamoto
,
Hisashi Yamanaka
,
Shigeru Kotake

(Centr Eur J Immunol 2014; 39 (4): 468-470)
Online publish date: 2014/12/15
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Background: We have demonstrated that a peptide, which we named ‘Peptide A’, derived from the extracellular domain of T-cell leukemia translocation-associated gene (TCTA) protein, inhibited human osteoclastogenesis.

Objective: In the current study, we examined whether this peptide inhibits the proliferation of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) or not.

Material and methods: Fibroblast-like synoviocytes obtained from five RA patients were cultured in the absence or presence of 1, 5, 10 µg/ml of peptide. We used 29-mer scrambled peptide as a control.

Results: The peptide inhibited the proliferation of RA FLS dose-dependently. On the other hand, the scrambled peptide showed no inhibition.

Conclusions: The peptide inhibits both human osteoclastogenesis and the proliferation of RA FLS. Thus, the peptide may be used for the therapy of both osteoporosis and synovitis of RA patients.

This is the first report of the new peptide we discovered, which inhibits both osteoclastogenesis and synovitis. Thus, this new peptide could be a new drug for patients with both osteoporosis and RA.
keywords:

osteoclast, arthritis, synovium, translocation-associated gene (TCTA), T-cell leukemia

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