Experimental immunology<br>Bacterial lipoprotein tolerance attenuates cardiac dysfunction in septic mice

Jing Zhou; Min Huang; Li-Qing Bi; Su-Ming Zhou; Yun-Lin Cheng; Guo-Xian Ding; Wei-Hao Sun

doi:10.5114/ceji.2012.30796

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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3/2012
vol. 37

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abstract:

Experimental immunology
Bacterial lipoprotein tolerance attenuates cardiac dysfunction in septic mice

Jing Zhou

,

Min Huang

,

Li-Qing Bi

,

Su-Ming Zhou

,

Yun-Lin Cheng

,

Guo-Xian Ding

,

Wei-Hao Sun

(Centr Eur J Immunol 2012; 37 (3): 209-220)

DOI: https://doi.org/10.5114/ceji.2012.30796

Online publish date: 2012/10/27

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In order to examine the effect of BLP tolerance on cardiac dysfunction in CLP-induced septic mice, cardiac function was measured via echocardiography at various time points following induction of sepsis by CLP in BLP-tolerant and control C57BL/6 mice. Levels of tumour necrosis factor α (TNF-α), interleukin 10 (IL-10) and Toll-like receptor 2 (TLR2)-myeloid differentiation factor 88 (MyD88)-dependent signaling molecules in the myocardium were also examined. Cardiac function was significantly decreased 6-12 h following CLP-induced sepsis compared with that of sham controls, with cardiac output decreasing from 0.50 ±0.06 ml/s to 0.16 ±0.04 ml/s at 6 h and 0.57 ±0.06 ml/s to 0.13 ±0.02 ml/s at 12 h, whereas BLP tolerance attenuated CLP-induced cardiac dysfunction at 12 h following CLP with cardiac output increasing from 0.13 ±0.02 ml/s to 0.26 ±0.05 ml/s at 12 h. TNF-α, IL-10 and TLR2-MyD88-dependent signaling molecules in the myocardium were not significantly different among BLP-tolerant or non-tolerant control groups. These findings suggest that low dose BLP pretreatment can attenuate cardiac dysfunction, increasing the survival rate of septic mice. This effect did not involve TNF-α, IL-10 or TLR2-MyD88-dependent cytokines. Bacterial lipoprotein pretreatment attenuated cardiac dysfunction in CLP sepsis. TNF-α, IL-10 and TLR2-MyD88-dependent signaling molecules did not contribute to cardiac dysfunction observed in CLP-induced sepsis.

keywords:

Experimental immunologyBacterial lipoprotein tolerance attenuates cardiac dysfunction in septic mice

Jing Zhou , Min Huang , Li-Qing Bi , Su-Ming Zhou , Yun-Lin Cheng , Guo-Xian Ding , Wei-Hao Sun

cardiac dysfunction, bacterial lipoprotein, Toll-like receptor 2, sepsis

Experimental immunology
Bacterial lipoprotein tolerance attenuates cardiac dysfunction in septic mice

Jing Zhou

,

Min Huang

,

Li-Qing Bi

,

Su-Ming Zhou

,

Yun-Lin Cheng

,

Guo-Xian Ding

,

Wei-Hao Sun