eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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vol. 38

Experimental immunology
Effect of hormone replacement therapy on the incidence and extent of Candida-associated denture stomatitis

Elżbieta Mierzwińska-Nastalska
Magdalena Golecka-Bąkowska
Małgorzata Bychawska
Eugeniusz Spiechowicz

(Centr Eur J Immunol 2013; 38 (2): 226-230)
Online publish date: 2013/07/08
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Menopause is a physical condition that occurs when the ovaries cease to function, decreasing the concentration of sex hormones. The deficiency of female steroid hormones also exerts an effect on the condition of oral mucosa.

The aim of the study was to evaluate the effect of hormone replacement therapy (HRT) on the incidence and extent of Candida-associated denture stomatitis in menopausal women who wear removable dentures. The study group was composed of 65 women, wearers of removable dentures, who were taking hormone replacement therapy. The control group comprised 65 women who also wear removable dentures, but are not using HRT. Clinical studies included an anamnesis, physical examinations of the oral mucosa condition and evaluation of dentures. Laboratory microbiological tests were performed, applying direct swabs collection from the oral mucosa. Moreover, the level of anti-nuclear antibodies against Candida albicans was analysed. Cases of denture stomatitis, characterized by a higher fungal growth rate, were found more frequent in patients wearing removable denture and taking HRT than in the control group. Patients wearing removable denture and taking hormone replacement therapy form a high-risk group in terms of fungal infections and inflammations of the oral mucosa. Therefore, they must have regular dental check-ups.

denture stomatitis, hormone replacement therapy, antibodies against C albicans

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