eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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vol. 37

Experimental immunology
The response of Toll-like receptors to glutamine in neonatal rat intestine

Abdulbaki Karaoglu
Turan Tunc
Gokhan Aydemir
Ferhat Cekmez
Mustafa Kul
Secil Aydinoz
Vural Kesik
Taner Ozgurtas
Serdar Umit Sarici

(Centr Eur J Immunol 2012; 37 (4): 298-302)
Online publish date: 2013/02/10
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Background: There are several barrier systems in the newborn gastrointestinal tract and one of the most important among these are the Toll-like receptors (TLRs). The aim of this study was to examine the effect of glutamine on Toll-like receptors 2 (TLR-2), TLR-4, and TLR-9 levels in the newborn gut.

Material and methods: Rats were randomly assigned to three experimental groups. Group I (control at day 0) (n = 9), group II (control at day 10) (n = 9): oral distilled water, group III (study group) (n = 9): oral glutamine (200 mg/kg/day). After 10 days, the ileojejunal segment was removed for biochemical analyses of TLR-2, -4 and -9.

Results: There was a significant difference between groups for the levels of TLRs. The level of TLR-9 was higher in group I than group II and in group III than group II. There was no statistically significant difference between group I and group III in terms of TLR-9 levels. There were no statistically significant differences between groups for the levels of TLR-2 and TLR-4.

Conclusions: Glutamine administration, by increasing the level of TLR-9, may prevent the increase in the level of TLR-4 in newborn rat intestine. Thus, it may play a protective role in the intestine and reduce the susceptibility to necrotizing enterocolitis (NEC), which is associated with the intensity of TLR-4 expression.

Toll-like receptor, glutamine, intestine, newborn rat

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