Postępy Dermatologii i Alergologii

Full text

5/2026 vol. 43
Original paper

Exploring UVA-mediated regulation of Hippo pathway kinases and stress signalling in human keratinocytes

  1. Department of Neurology, Central University Hospital, Lodz, Poland

  2. Department of Clinical Genetics, Medical University of Lodz, Poland

  3. Laboratory of Molecular Biology, Vet-Lab Brudzew, Brudzew, Poland

  4. Department of Dermatology, Paediatric Dermatology and Oncology, Medical University of Lodz, Poland

Adv Dermatol Allergol 2026; XLIII (5): 543-549

Data publikacji online: 2026/10/22
Article file
PDiA Exploring.pdf
  1. Rinnerthaler M, Bischof J, Streubel MK, et al. Oxidative stress in aging human skin. Biomolecules 2015; 5: 545-89.
  2. Cadet J, Douki T. Formation of UV-induced DNA damage contributing to skin cancer development. Photochem Photobiol Sci 2018; 17: 1816-41.
  3. Syed DN, Afaq F, Mukhtar H. Differential activation of signaling pathways by UVA and UVB radiation in normal human epidermal keratinocytes. Photochem Photobiol 2012; 88: 1184-90.
  4. Schuch AP, Moreno NC, Schuch NJ, et al. Sunlight damage to cellular DNA: focus on oxidatively generated lesions. Free Radic Biol Med 2017; 107: 110-24.
  5. Feng C, Chen X, Yin X, et al. Matrix metalloproteinases on skin photoaging. J Cosmet Dermatol 2024; 23: 3847-62.
  6. Thompson BJ. YAP/TAZ: drivers of tumor growth, metastasis, and resistance to therapy. BioEssays 2020; 42: e1900162.
  7. Tao W, Zhang S, Turenchalk GS, et al. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet 1999; 21: 177-81.
  8. Zheng Y, Pan D. The Hippo signaling pathway in development and disease. Dev Cell 2019; 50: 264-82.
  9. Rybarczyk A, Wierzbicki P, Kowalczyk A, Kmiec Z. Rola szlaku Hippo w kontroli proliferacji komórkowej i wielkoœci narz¹dów oraz jego zaburzenia w chorobach nowotworowych. Postepy Hig Med Dosw 2014; 68: 503-15.
  10. Ma S, Meng Z, Chen R, Guan KL. The hippo pathway: biology and pathophysiology. Annu Rev Biochem 2019; 88: 577-604.
  11. Huh HD, Kim DH, Jeong HS, Park HW. Regulation of TEAD transcription factors in cancer biology. Cells 2019; 8: 600.
  12. Elbediwy A, Vincent-Mistiaen ZI, Spencer-Dene B, et al. Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development 2016; 143: 1674-87.
  13. Song JJ, Lee YJ. Differential activation of the JNK signal pathway by UV irradiation and glucose deprivation. Cell Signal 2007; 19: 563-72.
  14. Ramaswamy NT, Ronai Z, Pelling JC. Rapid activation of JNK1 in UV-B irradiated epidermal keratinocytes. Oncogene 1998; 16: 1501-5.
  15. Assefa Z, Garmyn M, Bouillon R, et al. Differential stimulation of ERK and JNK activities by ultraviolet B irradiation and epidermal growth factor in human keratinocytes. J Invest Dermatol 1997; 108: 886-91.
  16. Hammouda MB, Ford AE, Liu Y, Zhang JY. The JNK signaling pathway in inflammatory skin disorders and cancer. Cells 2020; 9: 857.
  17. Ke H, Harris R, Coloff JL, et al. The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia. Cancer Res 2010; 70: 3080-8.
  18. Maglic D, Schlegelmilch K, Dost AF, et al. YAP-TEAD signaling promotes basal cell carcinoma development via a c-JUN/AP1 axis. EMBO J 2018; 37: 98642.
  19. You B, Yang YL, Xu Z, et al. Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells. Oncotarget 2015; 6: 4357-68.
  20. Greuber EK, Smith-Pearson P, Wang J, Pendergast AM. Role of ABL family kinases in cancer: from leukaemia to solid tumours. Nat Rev Cancer 2013; 13: 559-71.
  21. Juan WC, Hong W. Targeting the Hippo signaling pathway for tissue regeneration and cancer therapy. Genes 2016; 7: 55.
  22. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-8.
  23. Zhao Y, Sun B, Fu X, et al. YAP in development and disease: navigating the regulatory landscape from retina to brain. Biomed Pharmacother 2024; 175: 116703.
  24. Howard A, Bojko J, Flynn B, et al. Targeting the Hippo/YAP/TAZ signalling pathway: novel opportunities for therapeutic interventions into skin cancers. Exp Dermatol 2022; 31: 1477-99.
  25. Schlegelmilch K, Mohseni M, Kirak O, et al. Yap1 acts downstream of a-catenin to control epidermal proliferation. Cell 2011; 144: 782-95.
  26. Hamilton G, Yee KS, Scrace S, O’Neill E. ATM regulates a RASSF1A-dependent DNA damage response. Curr Biol 2009; 19: 2020-5.
  27. Okada N, Yabuta N, Suzuki H, et al. A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage. J Cell Sci 2011; 124: 57-67.
  28. Chiyoda T, Sugiyama N, Shimizu T, et al. LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression. J Cell Biol 2012; 197: 625-41.
  29. Zykova TA, Zhu F, Zhang Y, et al. Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2α (Ser51). Carcinogenesis 2007; 28: 1543-51..
  30. Djavaheri-Mergny M, Dubertret L. UV-A-induced AP-1 activation requires the Raf/ERK pathway in human NCTC 2544 keratinocytes. Exp Dermatol 2001; 10: 204-10.
  31. Silvers AL, Bachelor MA, Bowden GT. The role of JNK and p38 MAPK activities in UVA-induced signaling pathways leading to AP-1 activation and c-Fos expression, Neoplasia 2003; 5: 319-29.
  32. Keshet R, Reuven N, Shaul Y. c-Abl forces YAP to switch sides. Mol Cell Oncol 2015; 2: e995006.
  33. Huang T, Zhou F, Wang-Johanning F, et al. Depression accelerates the development of gastric cancer through reactive oxygen species-activated ABL1. Oncol Rep 2016; 36: 2435-43.
  34. Lan CCE, Hung YT, Fang AH, Ching-Shuang W. Effects of irradiance on UVA-induced skin aging. J Dermatol Sci 2019; 94: 220-8.
Copyright: © 2026 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Share
without publication fees