Abstract
Expression of CD1a, CD207, CD11b, CD11c, CD103, and HLA-DR receptors on the surface of dendritic cells in the skin of patients with atopic dermatitis
- Chair of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Faculty of Medicine, Nicolas Copernicus University in Torun, Poland
- Chair of Cosmetology and Aesthetic Dermatology, Ludwik Rydygier’s Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
- Chair and Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury, Olsztyn
Introduction
Atopic dermatitis (AD) is a chronic skin disorder of unknown etiopathogenesis. Its development is based on the influence of environmental factors, genetic and immunologic disorders. Undoubtedly, an important role is played by changes in quantitative and qualitative information on dendritic cells.
Aim
Assessment of CD1a, CD207, CD11b, CD11c, CD103, and HLA-DR receptors on the surface of dendritic cells in the skin of patients with atopic dermatitis.
Material and methods
The study group consisted of 45 patients with clinically diagnosed AD from whom biopsies were taken from the lesions. The control group was the material of 20 healthy people. To carry out the study the method of indirect immunofluorescence double staining reaction was used.
Results
Studied receptors gave positive reactions in both groups. The number of cells in healthy individuals was significantly lower than in patients. They also differed in appearance and location of the skin.
Conclusions
The CD1a/CD207 and CD1a/CD11c, CD1a/HLA-DR cell density was higher in AD patients compared to controls. There were differences in the location and appearance of the cells of AD patients compared to controls. All cells in the epidermis identified with antibodies CD1a, CD11c and CD207 were dendritic cells.
Keywords
atopic dermatitis, dendritic cells, Langerhans cells
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