eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2017
vol. 42
 
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abstract:
Clinical immunology

Expression of CD55, CD59, and CD35 on red blood cells of β-thalassaemia patients

Ayşegül Uğur Kurtoğllu
,
Belkls Koçtekin
,
Erdal Kurtoğlu
,
Mustafa Yildiz
,
Selen Bozkurt

(Cent Eur J Immunol 2017; 42 (1): 78-84)
Online publish date: 2017/05/08
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Aim of the study: β-thalassaemia (β-Thal) is considered a severe, progressive haemolytic anaemia, which needs regular blood transfusions for life expectancy. Complement-mediated erythrocyte destruction can cause both intravascular and extravascular haemolysis. Complement regulatory proteins protect cells from such effects of the complement system. We aimed to perform quantitative analysis of membrane-bound complement regulators, CD55 (decay accelerating factor – DAF), CD35 (complement receptor type 1 – CR1), and CD59 (membrane attack complex inhibitory factor – MACIF) on peripheral red blood cells by flow cytometry.

Material and methods: The present study was carried out on 47 β-thalassemia major (β-TM) patients, 20 β-thalassaemia intermedia (β-TI) patients, and 17 healthy volunteers as control subjects.

Results: CD55 levels of β-TM patients (58.64 ±17.06%) were significantly decreased compared to β-TI patients (83.34 ±13.82%) and healthy controls (88.57 ±11.69%) (p < 0.01). CD59 levels of β-TM patients were not significantly different than β-TI patients and controls, but CD35 levels were significantly lower in the β-TM patients (3.56 ±4.87%) and β-TI patients (12.48 ±9.19%) than in the control group (39.98 ±15.01%) (p < 0.01).

Conclusions: Low levels of CD55 and CD35 in thalassaemia major patients indicates a role for them in the aetiopathogenesis of haemolysis in this disease, and also this defect in a complement system may be responsible for the chronic complications seen in these patients.
keywords:

CD55, CD59, CD35, β-thalassemia

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