eISSN: 1732-2707
ISSN: 1730-1270
HIV & AIDS Review. International Journal of HIV-Related Problems
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SCImago Journal & Country Rank
2/2022
vol. 21
 
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abstract:
Original paper

Factors associated with discordant immuno-viral response in HIV-positive Peruvian adult people treated between 2005 and 2017

Roberto M. Carrasco Navarro
1
,
Raúl Héctor Montalvo Otivo
2, 3
,
Johana Ursula Clemente Lazo
1

1.
School of Medicine, Universidad Continental, Huancayo, Junín, Peru
2.
Universidad Nacional del Centro del Perú, Huancayo, Junín, Peru
3.
Chief of Department, Department of Tropical and Dermatological Infectious Diseases, Hospital Daniel Alcides Carrión-Huancayo, Junín, Peru
HIV AIDS Rev 2022; 21, 2: 164-168
Online publish date: 2022/04/22
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Introduction
Discordant immuno-viral response, defined as a failure in increasing more than 100 CD4+ cells/μl T lymphocytes with an undetectable viral load at one year after initiation of a highly active antiretroviral therapy (HAART), is associated with an increase in mortality in people living with HIV (PLWH). This study explored a cohort of HIV-positive patients in a Peruvian hospital to determine factors associated with discordant immuno-viral response.

Material and methods
A retrospective, analytical, cross-sectional single-site study was conducted, including PLWH receiving HAART with regular follow-up visits. In total, 310 PLWH, out of which 47 with a discordant response (DIR) and 263 with concordant immune response (CIR) fulfilled inclusion criteria for the study.

Results
Main characteristics of our population were: age of onset of HAART around 35 years, male and heterosexual. Moreover, age over 65 years, from different hospital, co-infection, opportunistic infections, and baseline CD4+ > 250 cells/μl were significantly associated with DIR. Multivariate regression analysis showed basal CD4+ > 250 cells/μl and opportunistic infections associated with DIR.

Conclusions
In our cohort, factors associated with the development of DIR are baseline CD4+ over 250 cells/μl and opportunistic infections.

keywords:

HIV, HAART, developing countries

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