Advances in Dermatology and Allergology
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ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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Original paper

Fractional CO2 laser augmented by polynucleotide and exosome-mimetic nanovesicles in atrophic acne scars: randomised comparative trial

Rena Raad Helmi
1
,
Rusul Sahib Hussien Mohammed
2
,
Wassan Nori
3

  1. Department of Dermatology, Faculty of Medicine, Mustansiriyah University, Baghdad, Iraq
  2. Department of Dermatology, Faculty of Medicine, Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq
  3. Department of Obstetrics and Gynaecology, College of Medicine, Mustansiriyah University, Baghdad, Iraq
Adv Dermatol Allergol
Online publish date: 2026/05/16
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1. Gozali MV, Zhou B, Luo D. Effective treatments of atrophic acne scars. J Clin Aesthet Dermatol 2015; 8: 33-40.
2. Lin L, Liao G, Chen J, Chen X. A systematic review and meta-analysis on the effects of the ultra-pulse CO2 fractional laser in the treatment of depressed acne scars. Ann Palliat Med 2022; 11: 743-55.
3. Liedtke FS, Rajapaksa SW. Major clinical evidence of the optimization of the use of CO2 fractional ablative laser with cells and molecules: a systematic review. MedNEXT J Med Health Sci 2023; 4. https://doi.org/10.54448/mdnt23301.
4. Haykal D, Wyles S, Garibyan L, et al. Exosomes in cosmetic dermatology: a review of benefits and challenges. J Drugs Dermatol 2025; 24: 12-8.
5. Lampridou S, Bassett S, Cavallini M, Christopoulos G. The effectiveness of polynucleotides in esthetic medicine: a systematic review. J Cosmetic Dermatol 2025; 24: e16721.
6. Palakurthi SS, Shah B, Kapre S, et al. A comprehensive review of challenges and advances in exosome-based drug delivery systems. Nanoscale Adv 2024; 6: 5803-26.
7. Serrano DR, Juste F, Anaya BJ, et al. Exosome-based drug delivery: a next-generation platform for cancer, infection, neurological and immunological diseases, gene therapy and regenerative medicine. Pharmaceutics 2025; 17: 1336.
8. Marques C, Porcello A, Cerrano M, et al. From polydeoxyribonucleotides (PDRNs) to polynucleotides (PNs): bridging the gap between scientific definitions, molecular insights, and clinical applications of multifunctional biomolecules. Biomolecules 2025; 15: 148.
9. Dreno B, Khammari A, Orain N, et al. ECCA grading scale: an original validated acne scar grading scale for clinical practice in dermatology. Dermatology 2007; 214: 46-51.
10. Noh YJ. A study on measuring the change of the response results in Likert 5-Point Scale measurement. J Korean Soc Inform Managage 2011; 28: 335-53.
11. Ferreira-Valente MA, Pais-Ribeiro JL, Jensen MP. Validity of four pain intensity rating scales. Pain 2011; 152: 2399-404.
12. Kwon HH, Yang SH, Lee J, et al. Combination treatment with human adipose tissue stem cell-derived exosomes and fractional CO2 laser for acne scars: a 12-week prospective, double-blind, randomized, split-face study. Acta Derm Venereol 2020; 100: adv00310.
13. Cho B. 1525 Combination of adipose stem cell exosomes (ASCE) with CO2 laser for acne scars: a 12-week prospective, double-blind, randomized, split-face study. J Investig Dermatol 2023; 143: S261.
14. Pastrana-López S. Mesenchymal stem cell-derived exosome treatment for acne scars: an alternative therapy. J Stem Cell Res 2024; 5(2 Suppl 2): S2.
15. Al Shammrie FF, Alhemshy LZ, Althawy MM, et al. The efficacy of MSC-derived exosome-based therapies in treating scars, aging and hyperpigmentation: a systematic review of human clinical outcomes. Reports 2025; 8: 268.
16. Squadrito F, Bitto A, Irrera N, et al. Pharmacological activity and clinical use of PDRN. Front Pharmacol 2017; 8: 224.
17. Khan A, Wang G, Zhou F, et al. Polydeoxyribonucleotide: a promising skin anti-aging agent. Chin J Plastic Reconstruct Surg 2022; 4: 187-93.
18. Kim ST. Comparison of polynucleotide and polydeoxyribonucleotide in dermatology: molecular mechanisms and clinical perspectives. Pharmaceutics 2025; 17: 1024.
19. Shin SM, Baek EJ, Kim KH, et al. Polydeoxyribonucleotide exerts opposing effects on ERK activity in human skin keratinocytes and fibroblasts. Mol Med Rep 2023; 28: 148.
20. Yang F, Wang M, Guan X. Exosomes and mimics as novel delivery platform for cancer therapy. Front Pharmacol 2022; 13: 1001417.
21. Li W, Li H, Fan L, et al. The potential application of exosomes as therapeutic agents, carriers, and biomarkers in skin diseases. Int J Nanomedecine 2025; 20: 12627-58.
22. Arsiwala S, Desai S. Fractional carbon dioxide laser: optimizing treatment outcomes for pigmented atrophic acne scars in skin of color. J Cutan Aesthet Surg 2019; 12: 85-94.
23. Moussa MH, Elhusseiny RM, El-Fiky SMR, Ahmed SES. Evaluation of the response of fractional carbon dioxide (CO2) laser and punch elevation technique in treatment of acne scars: a split-face comparative clinical, histopathological, and immune histochemical study. Egypt J Hosp Med 2017; 69: 1931-40.
24. Kubik P, Bighetti S, Bettolini L, et al. Effectiveness and safety of the use of 1470 nm laser therapy in patients suffering from acne scarring of the facial skin. Clin Cosmet Investig Dermatol 2025; 18: 543-51.
25. Antimisiaris SG, Mourtas S, Marazioti A. Exosomes and exosome-inspired vesicles for targeted drug delivery. Pharmaceutics 2018; 10: 218.
26. Bhargava S, Cunha PR, Lee J, Kroumpouzos G. acne scarring management: systematic review and evaluation of the evidence. Am J Clin Dermatol 2018; 19: 459-77. 
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