eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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SCImago Journal & Country Rank
3/2019
vol. 15
 
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Pediatrics
abstract:
Clinical research

Frequency of infections caused by ESBL-producing bacteria in pediatric ward – single center five-year observation

Agata Będzichowska
,
Jędrzej Przekora
,
Angelika Stapińska-Syniec
,
Aneta Guzek
,
Piotr Murawski
,
Katarzyna Jobs
,
Barbara Wróblewska
,
Bolesław Kalicki

Arch Med Sci 2019; 15 (3): 688–693
Online publish date: 2019/01/30
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Introduction
Infections caused by Enterobacteriaceae producing extended-spectrum -lactamases (ESBLs) are a serious therapeutic and clinical problem. An increasing role of ESBL(+) pathogens is observed in both community- and hospital-acquired infections. Aim of the study was to assess the incidence and the risk factors for ESBL(+) bacteria infection in a pediatric ward during a 5-year period.

Material and methods
The medical documentation data of patients hospitalized in the Department of Pediatrics, Pediatric Nephrology and Allergology between 2011 and 2015 were subjected to a retrospective analysis. Cases of ESBL(+) bacterial infections were analyzed in detail.

Results
0.57% (46) of all the hospitalizations (8015) during the 5-year observation period in our department were caused by ESBL (+) pathogens. It constituted 8.5% of all positive microbiological cultures obtained. The analysis revealed an increasing trend in the number of ESBL (+) infections throughout the observed period. 43.5% of patients were only asymptomatic carriers. In 71.7% urinary tract structural and functional abnormalities were present. 76.1% of patients had been hospitalized previously and 60.9% had undergone urinary tract invasive procedures.

Conclusions
The results confirm the rising trend of ESBL (+) infections during the observed period. ESBL (+) bacteria were isolated primarily in previously hospitalized children with particular reference to urinary tract invasive procedures during hospitalizations. Moreover, the study showed that patients with urogenital disorders and non-urinary chronic diseases are more susceptible to these priority pathogen infections.

keywords:

extended-spectrum -lactamases, multidrug resistance, risk factors, children, urinary tract infections

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