Advances in Dermatology and Allergology
eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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Letter to the Editor

From scalpel to blister: a diagnostic challenge of localized bullous pemphigoid following orthopaedic surgery

Aleksandra Wiktoria Bratborska
1, 2
,
Monika Bowszyc-Dmochowska
3
,
Marian Dmochowski
4

  1. Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland
  2. Doctoral School, Poznan University of Medical Sciences, Poznan, Poland
  3. Cutaneous Histopathology and Immunopathology Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland
  4. Autoimmune Blistering Dermatoses Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland
Adv Dermatol Allergol
DOI: https://doi.org/10.5114/ada.2026.159175
Online publish date: 2026/02/13
Article file
- From scalpel - Bratborska.pdf  [0.18 MB]
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1. Jałowska M, Spałek M, Bowszyc-Dmochowska M, et al. Involvement of palms and soles in patients with autoimmune bullous diseases: a comparative analysis of a diagnostically relevant localization. Front Immunol 2023; 14: 1227855.
2. Borradori L, Van Beek N, Feliciani C, et al. Updated S2 K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology (EADV). J Eur Acad Dermatol Venereol 2022; 36: 1689-704.
3. Camargo CM, Brotas AM, Ramos-e-Silva M, Carneiro S. Isomorphic phenomenon of Koebner: facts and controversies. Clin Dermatol 2013; 31: 741-9.
4. Moro F, Fania L, Sinagra JLM, et al. Bullous pemphigoid: trigger and predisposing factors. Biomolecules 2020; 10: 1432.
5. Kim YB, Choi HS, Cho HK, Seo GW. Diagnosis and treatment of bullous pemphigoid that developed twice after total knee replacement arthroplasty: a case report. BMC Musculoskelet Disord 2021; 22: 118.
6. Wieland CN, Comfere NI, Gibson LE, et al. Anti-bullous pemphigoid 180 and 230 antibodies in a sample of unaffected subjects. Arch Dermatol 2010; 146: 21-5.
7. Prüßmann W, Prüßmann J, Koga H, et al. Prevalence of pemphigus and pemphigoid autoantibodies in the general population. Orphanet J Rare Dis 2015; 10: 63.
8. Mai Y, Nishie W, Sato K, et al. Bullous pemphigoid triggered by thermal burn under medication with a dipeptidyl peptidase-IV inhibitor: a case report and review of the literature. Front Immunol 2018; 9: 542.
9. Massa MC, Freeark RJ, Kang JS. Localized bullous pemphigoid occurring in a surgical wound. Dermatol Nurs 1996; 8: 101-3.
10. Truss A, Papalexandris S, Gardner S, Harvey R. Localised bullous pemphigoid overlying knee arthroplasty: a diagnostic challenge. BMJ Case Rep 2019; 12: e227440.
11. Freeman BD, Rubin BG. Bullous pemphigoid after prosthetic vascular graft placement. Surgery 1998; 124: 112-3.
12. Anderson CK, Mowad CM, Goff ME, Pelle MT. Bullous pemphigoid arising in surgical wounds. Br J Dermatol 2001; 145: 670-2.
13. Yesudian PD, Dobson CM, Ahmad R, Azurdia RM. Trauma-induced bullous pemphigoid around venous access site in a haemodialysis patient. Clin Exp Dermatol 2002; 27: 70-2.
14. Korfitis C, Gregoriou S, Georgala S, et al. Trauma-induced bullous pemphigoid. Indian J Dermatol Venereol Leprol 2009; 75: 617-9.
15. Sen BB, Ekiz Ö, Rifaioglu EN, et al. Localized bullous pemphigoid occurring on surgical scars. Indian J Dermatol Venereol Leprol 2013; 79: 554.
16. Lo Schiavo A, Caccavale S, Alfano R, et al. Bullous pemphigoid initially localized around the surgical wound of an arthroprothesis for coxarthrosis. Int J Dermatol 2014; 53: e289-90.
17. Zeng R, Chen H, Jiang Y, Li M. Bullous pemphigoid after femur fracture surgery: a mere coincidence? Indian J Dermatol Venereol Leprol 2014; 80: 195.
18. Neville JA, Yosipovitch G. Flare of bullous pemphigoid in surgically treated skin. Cutis 2005; 75: 169-70.
19. Garrido Colmenero C, García Durá E, Aneiros Fernández J, Arias Santiago S. [Bullous pemphigoid on surgical scar]. Med Clin (Barc) 2015; 144: e1.
20. Singh D, Swann A. Bullous pemphigoid after bilateral forefoot surgery. Foot Ankle Spec 2015; 8: 68-72.
21. Murphy B, Walsh M, McKenna K. Bullous pemphigoid arising in lower leg vein graft incision site. J Card Surg 2016; 31: 57-9.
22. Wenzel D, Droms R, St John J, et al. Localized bullous pemphigoid after knee replacement surgery. Dermatol Online J 2021; 27: 13030/qt24c7f48h.
Copyright: © 2026 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

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