eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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4/2018
vol. 14
 
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abstract:
Clinical research

Glycoprotein Ibα Kozak polymorphism in patients presenting with early-onset acute coronary syndrome

Ebru Golcuk, Kivanc Yalin, Cansu Selcan Akdeniz, Erhan Teker, Başak Teker, Veysel Sabri Hancer, Ibrahim Altun, Murat Sezer, Reyhan Diz Kucukkaya, Aytac Oncul

Arch Med Sci 2018; 14, 4: 788–793
Online publish date: 2016/10/26
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Introduction
Glycoprotein Ibα (GPIbα) receptor is the chief molecule responsible for initial platelet adhesion to the subendothelium. A thymidine to cytosine single nucleotide substitution at position –5 from the ATG start codon characterizes the Kozak sequence polymorphism. The Kozak sequence polymorphism may increase the surface expression of GPIbα and contribute to thrombogenesis. We evaluated the allele frequencies of GPIbα Kozak sequence polymorphism in the Turkish population and examined the relationship between GPIbα Kozak sequence polymorphism and early-onset acute coronary syndrome (ACS).

Material and methods
This study enrolled 200 patients (122 male, 78 female, mean age: 39 ±5 years) and 200 healthy control subjects (110 male, 90 female, 41 ±4 years). The patient group was composed of patients admitted to our coronary care unit with early-onset ACS and patients who attended to our cardiology outpatient clinic after hospital discharge with a diagnosis of early-onset ACS.

Results
Kozak polymorphism frequencies in patients and control subjects did not differ significantly (23% versus 22.5%, p = 0.812, respectively). In patients who presented with non-ST elevation myocardial infarction (NSTEMI), the frequency of GPIbα Kozak polymorphism was borderline significantly higher when compared with patients who presented with ST elevation myocardial infarction (STEMI) (35% vs. 20%, p = 0.05, respectively). Allele frequencies of T and C were calculated to be 0.873 and 0.128.

Conclusions
Although the frequency of GPIbα Kozak polymorphism did not differ significantly in early-onset ACS patients versus control subjects, Kozak polymorphism frequency was borderline significantly higher in patients who presented with NSTEMI when compared to patients with STEMI.

keywords:

Turkish population, acute coronary syndrome, glycoprotein Ibα Kozak polymorphism

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