eISSN: 2353-5571
ISSN: 2353-4184
Health Psychology Report
Current issue Archive Articles in press About the journal Editorial board Journal's reviewers Abstracting and indexing Contact Instructions for authors Ethical standards and procedures

 
2/2020
vol. 8
 
Share:
Share:
more
 
 
abstract:
Original paper

HIV-related decreased brain activity during a semantic memory task is reflected in spontaneous brain functional connectivity

Anna R. Egbert
1, 2
,
Agnieszka Pluta
2, 3
,
Marta Sobańska
2
,
Natalia Gawron
4
,
Bogna Szymańska-Kotwica
5
,
Emilia Łojek
2
,
Harmonia Group
2, 3, 5, 6, 7, 8

1.
Faculty of Medicine, University of British Columbia, Vancouver, Canada
2.
Faculty of Psychology, University of Warsaw, Warsaw, Poland
3.
Institute of Physiology and Pathology of Hearing, World Hearing Center, Kajetany, Poland
4.
Department of Adult Clinical Psychology, Institute of Psychology, The Maria Grzegorzewska University, Warsaw, Poland
5.
The Central Hospital for Infectious Diseases, Warsaw, Poland
6.
The College of Medicine, The Ohio State University, Columbus, OH, USA
7.
The Cleveland Clinic, Cleveland, OH, USA
8.
Institute of Psychiatry and Neurology, Warsaw, Poland
Health Psychology Report, 8(2), 120–135
Online publish date: 2020/05/04
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Background
The primary goal was to examine HIV-related changes in brain activation during a semantic memory task. The secondary goal was to assess whether the functional connectivity of the brain regions showing altered activity during the semantic memory task is related to HIV serostatus.

Participants and procedure
The total group of 17 male subjects, aged on average 44 years, included 8 HIV+/cART+ and 9 demographically matched healthy comparators. Participants completed Famous Names Recognition task-functional magnetic resonance imaging (fMRI) and resting state fMRI.

Results
We found an effect of HIV status on brain activation during the semantic memory task, despite comparable accuracy and reaction time across groups. Compared to healthy individuals, in HIV+ participants recognition of famous names elicited less activity in the fronto-striatal network, particularly in the left caudate nucleus (p = .049), left inferior frontal gyrus (p = .047), left thalamus (p = .031) and right thalamus (p = .047), as well as in the left middle occipital gyrus (p = .028). Although an effect of HIV status on functional connectivity of the brain regions showing altered activity during semantic memory task was not observed, resting-state activation of those regions was significantly correlated with performance on cognitive domains of attention, executive functioning, psychomotor speed and semantic skills.

Conclusions
Our findings suggest the presence of functional brain network reorganization in HIV+/cART+ patients, particu-larly in subcortical regions of the fronto-striatal network, in the absence of neurocognitive decline.

keywords:

neurocognitive; cART; fMRI; functional brain connectivity; hand

Quick links
© 2020 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe