eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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SCImago Journal & Country Rank
4/2015
vol. 66
 
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abstract:
Original paper

Histopathological assessment of residual retroperitoneal mass removed in patients after chemotherapy for non-seminomatous germ cell tumours of the testis

Janusz Jaszczyński
,
Wacław Wilk
,
Anna Kruczak
,
Łukasz Wohadlo
,
Piotr Faron
,
Elżbieta Łuczyńska
,
Piotr Chłosta
,
Andrzej Stelmach
,
Jerzy Jakubowicz

Pol J Pathol 2015; 66 (4): 420-425
Online publish date: 2016/02/05
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Between 1990 and 1999, 182 men were treated for non-seminomatous germ cell testicular tumours. In 24 of them after chemotherapy a residual retroperitoneal mass was removed. In 14 of them additional immunohistochemical (IHC) examinations using antibodies against cytokeratins, vimentin, PLAP, CD30, AFP, βhCG, p53, and MIB-1 were performed. We compared the results of those additional studies with the results of routine histopathological examination. Histological assessment revealed most frequently (ca. 54% of cases) non-neoplastic lesions, i.e. fibro-cystic, necrotic or inflammatory tumours and lymphatic tissue. In about 33% of cases, surviving live neoplastic cells were found.
keywords:

germ cell tumours, retroperitoneal mass, immunohistochemistry

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