eISSN: 2299-0054
ISSN: 1895-4588
Videosurgery and Other Miniinvasive Techniques
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2/2021
vol. 16
 
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abstract:
Original paper

Hybrid esophagectomy for oesophageal cancer: long-term results. A single-centre experience

Lucie Hlaváčová
1
,
Radek Vrba
1
,
Čestmír Neoral
1
,
Rene Aujesky
1
,
Martin Stašek
1
,
Josef Chudáček
1
,
Katherine Vomáčková
1
,
David Vrána
2
,
Martin Sněhota
3, 4

1.
Department of Surgery I, University Hospital Olomouc, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic
2.
Department of Oncology, AGEL Hospital, Nový Jičín, Czech Republic
3.
Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic
4.
Centre for Telemedicine, Simulation and Clinical Skills, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic
Videosurgery Miniinv 2021; 16 (2): 297–304
Online publish date: 2020/11/16
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Introduction
The authors report long-term outcomes in patients who received neoadjuvant chemoradiotherapy and consequently underwent hybrid oesophagectomy for oesophageal cancer (OC).

Aim
To evaluate long-term outcomes in patients suffering from OC, who underwent hybrid oesophagectomy.

Material and methods
Our cohort consisted of patients suffering from OC, who received neoadjuvant chemoradiotherapy. Hybrid esophagectomy was performed 8–10 weeks after oncological treatment.

Results
Ninety-four patients underwent surgery for OC from 2011 to 2015. Histology revealed adenocarcinoma in 60.6%, squamous cell carcinoma (SCC) in 36.2%, and other type of cancer in 3.2%. Seventy-three (77.7%) patients with advanced stage (T3-4, N0-2, M0) were indicated to receive neoadjuvant chemoradiotherapy (nCRT). Trans-hiatal hybrid oesophagectomy was performed in 83 (88.3%) patients. Transthoracic hybrid oesophagectomy was performed in 11 (11.7%) patients. Histology of the resected specimens of 18 (24.7%) patients did not reveal OC, i.e. pathological complete response (pCR). In our cohort, we proved an association between occurrence of pCR and age as well as disease-free survival (DFS). The patients who presented with pCR were significantly younger – below 60 years of age (p = 0.017). They also showed significantly higher mean DFS (p = 0.004).

Conclusions
Combined oesophagectomy with neoadjuvant chemoradiotherapy results in a better long-term outcome in patients suffering from oesophageal cancer. In our set of patients who underwent hybrid esophagectomy, satisfactory short-term and especially long-term results of surgical treatment for oesophageal cancer were observed.

keywords:

oesophageal cancer, hybrid oesophagectomy, pathological complete response, long-term outcome

  
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