eISSN: 1731-2531
ISSN: 1642-5758
Anaesthesiology Intensive Therapy
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Journal's reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank

 
4/2021
vol. 53
 
Share:
Share:
more
 
 
abstract:
Original paper

Hypertonic saline for goal-directed therapy guided by Capstesia in gastrointestinal surgery: a randomized controlled study

Hany Mohammed El-Hadi Shoukat Mohammed
1
,
Yasser Mohamed Hamed El Halafaway
1
,
Abdelrahman Mohamed Saad
1
,
Essam Abdelhalem Mahran
2

1.
Faculty of Medicine, Cairo University, Cairo, Egypt
2.
NCI (National Cancer Institute), Cairo University, Cairo, Egypt
Anaesthesiol Intensive Ther 2021; 53, 4: 296–303
Online publish date: 2021/05/17
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
Goal-directed fluid therapy (GDT) aims to increase stroke volume and cardiac output and improve gut perfusion. Hypertonic saline (HS) can restore the macro-and micro-circulation, increase myocardial contractility, and reduce tissue edema. Therefore, we aimed to investigate the efficacy of intraoperative HS administration in GDT during gastrointestinal (GI) surgery.

Material and methods
Forty patients who underwent GI surgery under general anesthesia were enrolled in this randomized controlled study. Patients received boluses of either lactated Ringer’s (LR) solution, or 3% HS solution guided by an algorithm dependent on a smartphone application for estimations of pulse pressure variation (PPV). The primary outcome was the total amount of administered intraoperative crystalloid fluids in both groups. Serum sodium and time to first bowel movement after surgery were also recorded.

Results
In the HS group, patients received 1262.50 ± 318.25 mL of crystalloids compared to 2667.50 ± 670.29 mL received by patients in the LR group (P < 0.001). The mean time of first bowel movement in hours was 44.40 (± 14.09) in the HS group compared to 55.80 (± 18.38) in the LR group, but the P-value was > 0.05.

Conclusions
The use of HS solution for GDT in GI surgery resulted in a beneficial reduction in positive fluid balance and possibly earlier resumption of bowel movements.

keywords:

fluids, saline, hypertonic, fluids, goal-directed therapy, fluids, responsiveness, hemodynamic monitoring, pulse pressure variation, Capstesia

Quick links
© 2021 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.