eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
2/2009
vol. 60
 
Share:
Share:
more
 
 
abstract:

Hypoxia-inducible factor-1, a new possible important factor in neoplasia

Hanna Rekwirowicz
,
Andrzej Marszałek

Pol J Pathol 2009; 2: 61-66
Online publish date: 2009/08/30
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Hypoxia-inducible factor-1 (HIF-1) is one of the major factors responsible for the activation of compensation processes during cell hypoxia. Hypoxia-inducible factor-1 is a dimeric protein complex and serves as a transcription factor regulator for many target genes. Under normoxic conditions it is constitutively produced and degraded by the ubiquitin-proteasome system. But under hypoxic conditions HIF-1 becomes stabilized. The expression of HIF-1 increases vascularization of the ischaemic area and regulates anaerobic metabolism. The same processes were observed in neoplastic tissues. Hypoxia-inducible factor-1 and its participation in neoplasia, the inhibition and stimulation of its transcriptional activity, attracts the attention of many scientists as the understanding of its function in tumour progression could be used in the future for preparation of new antineoplastic therapies.
keywords:

hypoxia-inducible factor-1, neoplasia

Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.